Literature DB >> 3919445

Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate.

R J Levy, J Wolfrum, F J Schoen, M A Hawley, S A Lund, R Langer.   

Abstract

Bioprostheses fabricated from porcine aortic valves are widely used to replace diseased heart valves. Calcification is the principal cause of the clinical failure of these devices. In the present study, inhibition of the calcification of bioprosthetic heart valve cusps implanted subcutaneously in rats was achieved through the adjacent implantation of controlled-release matrices containing the anticalcification agent ethanehydroxydiphosphonate dispersed in a copolymer of ethylene-vinyl acetate. Prevention of calcification was virtually complete, without the adverse effects of retarded bone and somatic growth that accompany systemic administration of ethanehydroxydiphosphonate.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3919445     DOI： 10.1126/science.3919445

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response.

Authors:  Yoshinori Onuki; Upkar Bhardwaj; Fotios Papadimitrakopoulos; Diane J Burgess
Journal:  J Diabetes Sci Technol       Date:  2008-11

2.  Calcification of subcutaneously implanted type I collagen sponges. Effects of formaldehyde and glutaraldehyde pretreatments.

Authors:  R J Levy; F J Schoen; F S Sherman; J Nichols; M A Hawley; S A Lund
Journal:  Am J Pathol       Date:  1986-01       Impact factor: 4.307

3.  Calcification of bovine pericardium used in cardiac valve bioprostheses. Implications for the mechanisms of bioprosthetic tissue mineralization.

Authors:  F J Schoen; J W Tsao; R J Levy
Journal:  Am J Pathol       Date:  1986-04       Impact factor: 4.307

4.  Bisacylphosphonates inhibit hydroxyapatite formation and dissolution in vitro and dystrophic calcification in vivo.

Authors:  G Golomb; A Schlossman; H Saadeh; M Levi; J M Van Gelder; E Breuer
Journal:  Pharm Res       Date:  1992-01       Impact factor: 4.200

5.  The effect of heparin hydrogel embedding on glutaraldehyde fixed bovine pericardial tissues: Mechanical behavior and anticalcification potential.

Authors:  Adel Badria; Petros Koutsoukos; Sotirios Korossis; Dimosthenis Mavrilas
Journal:  J Mater Sci Mater Med       Date:  2018-11-09       Impact factor: 3.896

6.  Iontophoresis for modulation of cardiac drug delivery in dogs.

Authors:  V Labhasetwar; T Underwood; S P Schwendeman; R J Levy
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

7.  Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia.

Authors:  D B Masters; C B Berde; S Dutta; T Turek; R Langer
Journal:  Pharm Res       Date:  1993-10       Impact factor: 4.200

8.  Inhibition of mineralization of glutaraldehyde-pretreated bovine pericardium by AlCl3. Mechanisms and comparisons with FeCl3, LaCl3, and Ga(NO3)3 in rat subdermal model studies.

Authors:  C L Webb; F J Schoen; W E Flowers; A C Alfrey; C Horton; R J Levy
Journal:  Am J Pathol       Date:  1991-04       Impact factor: 4.307

Review 9.  1994 Whitaker Lecture: polymers for drug delivery and tissue engineering.

Authors:  R Langer
Journal:  Ann Biomed Eng       Date:  1995 Mar-Apr       Impact factor: 3.934

10.  Conversion of ouabain-induced ventricular tachycardia in dogs with epicardial lidocaine: pharmacodynamics and functional effects.

Authors:  A Sintov; W A Scott; K P Gallagher; R J Levy
Journal:  Pharm Res       Date:  1990-01       Impact factor: 4.200
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.