Literature DB >> 3919090

Immune attack on pancreatic islet transplants in the spontaneously diabetic BioBreeding/Worcester (BB/W) rat is not MHC restricted.

E J Weringer, A A Like.   

Abstract

Spontaneous diabetes mellitus in the BB/W rat is preceded by lymphocytic insulitis that destroys pancreatic beta cells. Cultured pancreatic islets and adrenal cortex from inbred rats of variable MHC were transplanted to RT1/u BB/W rats without allograft rejection. Islet grafts from RT1/u and non-RT1/u rats evidenced lymphocytic insulitis in BB/W recipients that became diabetic or evidenced lymphocytic insulitis within endogenous islets. These findings suggest that BB immune insulitis is not MHC restricted and may be directed against islet transplants from non-RT1/u animals.

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Year:  1985        PMID： 3919090

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  15 in total

1.  Formation of insulin-secreting, Sertoli-enriched tissue constructs by microgravity coculture of isolated pig islets and rat Sertoli cells.

Authors:  D F Cameron; J J Hushen; S J Nazian
Journal:  In Vitro Cell Dev Biol Anim       Date:  2001-09       Impact factor: 2.416

2.  Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Authors:  E J Weringer; A A Like
Journal:  Am J Pathol       Date:  1986-10       Impact factor: 4.307

Review 3.  The role of interleukin-1 in the pathogenesis of IDDM.

Authors:  T Mandrup-Poulsen
Journal:  Diabetologia       Date:  1996-09       Impact factor: 10.122

Review 4.  Mechanisms of autoimmunity in insulin-dependent diabetes mellitus.

Authors:  J F Bach
Journal:  Clin Exp Immunol       Date:  1988-04       Impact factor: 4.330

5.  Prevention and suppression of autoimmune pancreatic beta-cell destruction in BB rats by syngeneic lymphocytes obtained from long-term normoglycaemic donors.

Authors:  B Kuttler; A Dunger; H D Volk; T Diamantstein; H J Hahn
Journal:  Diabetologia       Date:  1991-02       Impact factor: 10.122

6.  Pancreas transplantation. An immunohistologic and histopathologic examination of 100 grafts.

Authors:  R K Sibley; D E Sutherland
Journal:  Am J Pathol       Date:  1987-07       Impact factor: 4.307

Review 7.  Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.

Authors:  Marc Y Donath; Joachim Størling; Kathrin Maedler; Thomas Mandrup-Poulsen
Journal:  J Mol Med (Berl)       Date:  2003-07-18       Impact factor: 4.599

8.  Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.

Authors:  E J Weringer; A A Like
Journal:  Am J Pathol       Date:  1988-08       Impact factor: 4.307

9.  Spontaneous diabetes mellitus in the Bio-Breeding/Worcester rat. Evidence in vitro for natural killer cell lysis of islet cells.

Authors:  P MacKay; J Jacobson; A Rabinovitch
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

10.  The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

Authors:  Y Wang; O Pontesilli; R G Gill; F G La Rosa; K J Lafferty
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205
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