Literature DB >> 3918884

Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin.

J D Walton, E D Earle, H Stähelin, A Grieder, A Hirota, A Suzuki.   

Abstract

Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide alpha-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.

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Year:  1985        PMID： 3918884     DOI： 10.1007/bf02004498

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Mass spectrometric determination of amino acid sequence in Cyl-2, a novel cyclotetrapeptide from Cylindrocladium scoparium.

Authors:  A Hirota; A Suzuki; K Aizawa; S Tamura
Journal:  Biomed Mass Spectrom       Date:  1974-02

2.  [Isolation and structural clarification of chlamydocin].

Authors:  A Closse; R Huguenin
Journal:  Helv Chim Acta       Date:  1974-04-27       Impact factor: 2.164

3.  The structure and conformation of HC-toxin.

Authors:  M Kawai; D H Rich; J D Walton
Journal:  Biochem Biophys Res Commun       Date:  1983-03-16       Impact factor: 3.575

4.  Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.

Authors:  A Grieder; R Maurer; H Stähelin
Journal:  Cancer Res       Date:  1977-09       Impact factor: 12.701

5.  Purification and structure of the host-specific toxin from Helminthosporium carbonum race 1.

Authors:  J D Walton; E D Earle; B W Gibson
Journal:  Biochem Biophys Res Commun       Date:  1982-08       Impact factor: 3.575

6.  Conformational studies of cyclic tetrapeptides. Evidence for a bis gamma-turn conformation for chlamydocin and Ala4-chlamydocin in nonpolar solvents.

Authors:  D H Rich; M Kawai; R D Jasensky
Journal:  Int J Pept Protein Res       Date:  1983-01

7.  Cytostatic activity of chlamydocin, a rapidly inactivated cyclic tetrapeptide.

Authors:  H Stähelin; A Trippmacher
Journal:  Eur J Cancer       Date:  1974-12       Impact factor: 9.162
  7 in total
  4 in total

1.  New antitumoral cyclopeptides.

Authors:  E Bernardi; J L Fauchère; G Atassi; P Viallefont; R Lazaro
Journal:  Amino Acids       Date:  1994-10       Impact factor: 3.520

2.  Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi.

Authors:  Dipnath Baidyaroy; Gerald Brosch; Stefan Graessle; Patrick Trojer; Jonathan D Walton
Journal:  Eukaryot Cell       Date:  2002-08

3.  Histone Hyperacetylation in Maize in Response to Treatment with HC-Toxin or Infection by the Filamentous Fungus Cochliobolus carbonum.

Authors:  R. F. Ransom; J. D. Walton
Journal:  Plant Physiol       Date:  1997-11       Impact factor: 8.340

4.  Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.

Authors:  G Brosch; R Ransom; T Lechner; J D Walton; P Loidl
Journal:  Plant Cell       Date:  1995-11       Impact factor: 11.277
  4 in total

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