Literature DB >> 3918883

Effects of beta-hydroxybutyrate on rat embryos grown in culture.

E A Sheehan, F Beck, C A Clarke, M Stanisstreet.   

Abstract

In order to investigate further the relationship between maternal diabetes and fetal malformation, rat embryos were grown in vitro in the presence of beta-hydroxybutyrate, one of the ketone bodies produced by diabetics. At 10 mM, beta-hydroxybutyrate produced minor abnormalities and at 20 mM it produced major abnormalities in rat embryos.

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Year:  1985        PMID： 3918883     DOI： 10.1007/bf02002633

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

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Authors:  L ANGERVALL
Journal:  Acta Endocrinol Suppl (Copenh)       Date:  1959

2.  Permeability of the rabbit placenta to glucose and fructose.

Authors:  J DAVIES
Journal:  Am J Physiol       Date:  1955-06

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Authors:  D A New; P T Coppola; D L Cockroft
Journal:  J Reprod Fertil       Date:  1976-09

4.  Culture of explanted rat embryos in rotating tubes.

Authors:  D A New; P T Coppola; S Terry
Journal:  J Reprod Fertil       Date:  1973-10

5.  Effects of glucose on rat embryos in culture.

Authors:  E A Garnham; F Beck; C A Clarke; M Stanisstreet
Journal:  Diabetologia       Date:  1983-09       Impact factor: 10.122

6.  The British survey of diabetic pregnancies.

Authors:  R W Beard; C Lowy
Journal:  Br J Obstet Gynaecol       Date:  1982-10

Review 7.  Factors affecting risks of congenital malformations. II. Effect of maternal diabetes on congenital malformations.

Authors:  C S Chung; N C Myrianthopoulos
Journal:  Birth Defects Orig Artic Ser       Date:  1975

8.  Embryonic malformations in rats, resulting from maternal diabetes: preliminary observations.

Authors:  E M Deuchar
Journal:  J Embryol Exp Morphol       Date:  1977-10

9.  Teratogenic effects of excess glucose on head-fold rat embryos in culture.

Authors:  D L Cockroft; P T Coppola
Journal:  Teratology       Date:  1977-10

10.  CONGENITAL MALFORMATIONS IN NEWBORN INFANTS OF DIABETIC WOMEN. CORRELATION WITH MATERNAL DIABETIC VASCULAR COMPLICATIONS.

Authors:  L M PEDERSEN; I TYGSTRUP; J PEDERSEN
Journal:  Lancet       Date:  1964-05-23       Impact factor: 79.321
  10 in total
  6 in total

Review 1.  Congenital malformations in offspring of diabetic mothers--animal and human studies.

Authors:  Ulf J Eriksson; Jonas Cederberg; Parri Wentzel
Journal:  Rev Endocr Metab Disord       Date:  2003-03       Impact factor: 6.514

2.  Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate.

Authors:  Kieran Clarke; Kirill Tchabanenko; Robert Pawlosky; Emma Carter; Nicholas S Knight; Andrew J Murray; Lowri E Cochlin; M Todd King; Andrea W Wong; Ashley Roberts; Jeremy Robertson; Richard L Veech
Journal:  Regul Toxicol Pharmacol       Date:  2012-04-11       Impact factor: 3.271

3.  Recovery by mouse embryos following teratogenic exposure to ketosis.

Authors:  L Shum; T W Sadler
Journal:  Diabetologia       Date:  1991-05       Impact factor: 10.122

4.  High glucose concentration inhibits migration of rat cranial neural crest cells in vitro.

Authors:  N Suzuki; K Svensson; U J Eriksson
Journal:  Diabetologia       Date:  1996-04       Impact factor: 10.122

5.  Effects of hyperglycaemia on sorbitol and myo-inositol contents of cultured embryos: treatment with aldose reductase inhibitor and myo-inositol supplementation.

Authors:  M Hashimoto; S Akazawa; M Akazawa; M Akashi; H Yamamoto; Y Maeda; Y Yamaguchi; H Yamasaki; D Tahara; T Nakanishi
Journal:  Diabetologia       Date:  1990-10       Impact factor: 10.122

6.  Embryonic growth impaired by maternal hypoglycemia during early organogenesis in normal and diabetic rats.

Authors:  M Kawaguchi; K Tanigawa; O Tanaka; Y Kato
Journal:  Acta Diabetol       Date:  1994-09       Impact factor: 4.280
  6 in total

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