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Literature DB >> 3918707

Hepatitis B virus DNA and e antigen in serum from blood donors in the United Kingdom positive for hepatitis B surface antigen.

T J Harrison, V Bal, E G Wheeler, T J Meacock, J F Harrison, A J Zuckerman.

Abstract

Serum samples from 214 blood donors in the United Kingdom who were carriers of hepatitis B surface antigen (HBsAg) were examined for hepatitis B virus deoxyribonucleic acid (DNA) by DNA:DNA hybridisation and for hepatitis B e antigen (HBeAg) and its antibody. One fifth of the donors carried infectious virus in their circulation. The presence of hepatitis B virus DNA correlated well with that of HBeAg, although hepatitis B virus DNA was found in five serum samples that were negative for HBeAg. It is concluded that analysis of serum samples for hepatitis B virus DNA by hybridisation should be the method of choice for determining whether carriers of HBsAg are infectious.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1985 PMID： 3918707 PMCID： PMC1417609 DOI： 10.1136/bmj.290.6469.663

Source DB: PubMed Journal: Br Med J (Clin Res Ed) ISSN： 0267-0623

12 in total

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Authors: J Scotto; M Hadchouel; C Hery; J Yvart; P Tiollais; C Brechot
Journal: Hepatology Date: 1983 May-Jun Impact factor: 17.425

2. Relationship between HBV-specific DNA polymerase and HBe antigen/antibody system in chronic HBV infection: factors determining selection of patients and outcome of antiviral therapy.

Authors: A Craxi; I V Weller; M F Bassendine; M J Fowler; J Monjardino; H C Thomas; S Sherlock
Journal: Gut Date: 1983-02 Impact factor: 23.059

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Authors: C R Howard; A R Zanetti; A J Zuckerman
Journal: J Med Virol Date: 1978 Impact factor: 2.327

4. Significance of tests for HBeAg and anti-HBe in HBsAg positive blood donors.

Authors: B C Dow; I Macvarish; A Barr; R J Crawford; R Mitchell
Journal: J Clin Pathol Date: 1980-11 Impact factor: 3.411

5. Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure.

Authors: H J Alter; L B Seeff; P M Kaplan; V J McAuliffe; E C Wright; J L Gerin; R H Purcell; P V Holland; H J Zimmerman
Journal: N Engl J Med Date: 1976-10-21 Impact factor: 91.245

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Authors: P M Kaplan; R L Greenman; J L Gerin; R H Purcell; W S Robinson
Journal: J Virol Date: 1973-11 Impact factor: 5.103

7. Detection and characterization of hepatitis B virus DNA in serum of HBe antigen-negative HBsAg carriers.

Authors: R Tur-Kaspa; E Keshet; M Eliakim; D Shouval
Journal: J Med Virol Date: 1984 Impact factor: 2.327

8. Differential activation of hepatitis B DNA polymerase by detergent and salt.

Authors: S Z Hirschman; M Gerber; E Garfinkel
Journal: J Med Virol Date: 1978 Impact factor: 2.327

9. Assay of HBV DNA in the plasma of HBV-carrier chimpanzees superinfected with non-A, non-B hepatitis.

Authors: T J Harrison; K N Tsiquaye; A J Zuckerman
Journal: J Virol Methods Date: 1983-05 Impact factor: 2.014

10. Detection of hepatitis B virus DNA directly in human serum by a simplified molecular hybridization test: comparison to HBeAg/anti-HBe status in HBsAg carriers.

Authors: H M Lieberman; D R LaBrecque; M C Kew; S J Hadziyannis; D A Shafritz
Journal: Hepatology Date: 1983 May-Jun Impact factor: 17.425

10 in total

1. Infection with hepatitis B virus after open heart surgery.

Authors: M B Prentice; A J Flower; G M Morgan; K G Nicholson; B Rana; R K Firmin; C J Mitchell
Journal: BMJ Date: 1992-03-21

2. Prevalence of HBeAg, anti-HBe serological markers and HBV-DNA in asymptomatic carriers in Ethiopia.

Authors: M Rapicetta; K Hailù; G Morace; L Bisanti; A M Di Rienzo; A R Ciccaglione; D Bekura; P Pasquini; G B Rossi
Journal: Eur J Epidemiol Date: 1989-12 Impact factor: 8.082

3. HBV-DNA, HBeAg/anti-HBe serological status in hepatitis B chronic individuals from central Italy.

Authors: M Rapicetta; V di Nardo; C Rozera; G Marinucci; D Francisci; B Sarrecchia; C Ricci; F Albertoni
Journal: Epidemiol Infect Date: 1990-06 Impact factor: 2.451

4. The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation.

Authors: H J Schlicht; J Salfeld; H Schaller
Journal: J Virol Date: 1987-12 Impact factor: 5.103