Literature DB >> 3918543

Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis.

G Husby, R C Williams.   

Abstract

Synovial tissues were studied, using immunofluorescence techniques, for localization of lymphocytic infiltrates and immune reactants, including C3, C5b-9, C9, and Ia antigen. Tissue distribution of interleukin-2 (IL-2) and gamma-interferon was also determined, using mouse monoclonal antibodies. IL-2 was found in association with OKT8 and OKT4 T cells, and gamma-interferon was noted in association with T cells, B cells, and macrophages. Staining both for IL-2 and for gamma-interferon was surprisingly faint in view of the intensity of lymphocytic infiltration.

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Year:  1985        PMID： 3918543     DOI： 10.1002/art.1780280212

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  28 in total

1.  Interindividual and intra-articular variation of proinflammatory cytokines in patients with rheumatoid arthritis: potential implications for treatment.

Authors:  A K Ulfgren; L Gröndal; S Lindblad; M Khademi; O Johnell; L Klareskog; U Andersson
Journal:  Ann Rheum Dis       Date:  2000-06       Impact factor: 19.103

2.  Immunohistochemistry of normal human knee synovium: a quantitative study.

Authors:  J A Singh; T Arayssi; P Duray; H R Schumacher
Journal:  Ann Rheum Dis       Date:  2004-07       Impact factor: 19.103

3.  Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis.

Authors:  A K Ulfgren; S Lindblad; L Klareskog; J Andersson; U Andersson
Journal:  Ann Rheum Dis       Date:  1995-08       Impact factor: 19.103

4.  Localization of interferons and interleukin 2 in polymyositis and muscular dystrophy.

Authors:  D A Isenberg; D Rowe; M Shearer; D Novick; P C Beverley
Journal:  Clin Exp Immunol       Date:  1986-02       Impact factor: 4.330

5.  Differential expression of Ia antigens by rheumatoid synovial lining cells.

Authors:  G R Burmester; B Jahn; P Rohwer; J Zacher; R J Winchester; J R Kalden
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808

6.  Immunoregulatory lymphokines in rheumatoid joints. II. Production by and responsiveness to interleukin-2 of eluted synovial tissue cells.

Authors:  J Hovdenes; T Egeland
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631

7.  Interleukin 2 inhibitor in synovial fluid.

Authors:  P Emery; K C Gentry; A Kelso; I R Mackay
Journal:  Clin Exp Immunol       Date:  1988-04       Impact factor: 4.330

8.  Localization of T lymphocytes and macrophages expressing IL-1, IL-2 receptor, IL-6 and TNF in human aortic intima. Role of cell-mediated immunity in human atherogenesis.

Authors:  H Kishikawa; T Shimokama; T Watanabe
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

9.  Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1 beta production by synovial T cells.

Authors:  E Robinson; E C Keystone; T J Schall; N Gillett; E N Fish
Journal:  Clin Exp Immunol       Date:  1995-09       Impact factor: 4.330

10.  Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase C.

Authors:  K Hashimoto; C E Whitehurst; T Matsubara; K Hirohata; P E Lipsky
Journal:  J Clin Invest       Date:  1992-06       Impact factor: 14.808
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