Literature DB >> 3917575

Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors.

M Mercola, J Goverman, C Mirell, K Calame.   

Abstract

Enhancer sequences are regulatory regions that greatly increase transcription of certain eukaryotic genes. An immunoglobulin heavy-chain variable gene segment is moved from a region lacking enhancer activity to a position adjacent to the known heavy-chain enhancer early in B-cell maturation. In lymphoid cells, the heavy-chain and SV40 enhancers bind a common factor essential for enhancer function. In contrast, fibroblast cells contain a functionally distinct factor that is used by the SV40 but not by the heavy-chain enhancer. The existence of different factors in these cells may explain the previously described lymphoid cell specificity of the heavy-chain enhancer.

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Year:  1985        PMID： 3917575     DOI： 10.1126/science.3917575

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  106 in total

1.  Tissue-specific expression of the skeletal alpha-actin gene involves sequences that can function independently of MyoD and Id.

Authors:  G E Muscat; J Emery; E S Collie
Journal:  Gene Expr       Date:  1992

2.  Interaction of epsilon-globin cis-acting control elements with erythroid-specific regulatory macromolecules.

Authors:  J Wu; G J Grindlay; C Johnson; M Allan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

3.  Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2.

Authors:  B K Yoza; R G Roeder
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

4.  Enhancer sequences of a retroviral vector determine expression of a gene in multipotent hematopoietic progenitors and committed erythroid cells.

Authors:  C A Holland; P Anklesaria; M A Sakakeeny; J S Greenberger
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

5.  trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin alpha gene.

Authors:  J L Jameson; P J Deutsch; G D Gallagher; R C Jaffe; J F Habener
Journal:  Mol Cell Biol       Date:  1987-09       Impact factor: 4.272

6.  Tissue-specific expression of the human alpha 1-antitrypsin gene is controlled by multiple cis-regulatory elements.

Authors:  R F Shen; Y Li; R N Sifers; H Wang; C Hardick; S Y Tsai; S L Woo
Journal:  Nucleic Acids Res       Date:  1987-10-26       Impact factor: 16.971

7.  Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity.

Authors:  T Kadesch; P Zervos; D Ruezinsky
Journal:  Nucleic Acids Res       Date:  1986-10-24       Impact factor: 16.971

8.  Multiple hepatic trans-acting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene.

Authors:  Y Li; R F Shen; S Y Tsai; S L Woo
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

9.  The MHC class II E beta promoter: a complex arrangement of positive and negative elements determines B cell and interferon-gamma (IFN-gamma) regulated expression.

Authors:  D Thanos; M Gregoriou; D Stravopodis; K Liapaki; T Makatounakis; J Papamatheakis
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

10.  Molecular prioritization strategies to identify functional genetic variants in the cardiovascular disease-associated expression QTL Vanin-1.

Authors:  Belinda J Kaskow; Luke A Diepeveen; J Michael Proffitt; Alexander J Rea; Daniela Ulgiati; John Blangero; Eric K Moses; Lawrence J Abraham
Journal:  Eur J Hum Genet       Date:  2013-09-18       Impact factor: 4.246
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