Literature DB >> 3916517

Why are lung allografts more vigorously rejected than hearts?

J Prop, K Kuijpers, A H Petersen, H L Bartels, P Nieuwenhuis, C R Wildevuur.   

Abstract

The fact that lungs are more prone to rejection than hearts was studied in a fully allogeneic rat strains combination. Between these strains, lung rejection was significantly faster than that of the heart (mean survival time of 4.0 versus 6.8 days). The mucosal immune system transplanted within the lung allograft was found to intensify the recipient's immune response in several ways. First, it facilitates the infiltration of the graft by recipient lymphocytes. Secondly, it provides a strong stimulus for the local immune response in the graft itself, and lastly, the dissimination of donor lymphocytes from the graft into the recipient generates a systemic immune response.

Entities:  

Mesh：

Year:  1985        PMID： 3916517

Source DB:  PubMed          Journal:  J Heart Transplant        ISSN： 0887-2570


  8 in total

Review 1.  Cell migration, chimerism, and graft acceptance.

Authors:  T E Starzl; A J Demetris; N Murase; S Ildstad; C Ricordi; M Trucco
Journal:  Lancet       Date:  1992-06-27       Impact factor: 79.321

Review 2.  The pathology of heart and heart and lung transplantation--an update.

Authors:  S Stewart; N Cary
Journal:  J Clin Pathol       Date:  1991-10       Impact factor: 3.411

Review 3.  Chronic rejection. A general overview of histopathology and pathophysiology with emphasis on liver, heart and intestinal allografts.

Authors:  A J Demetris; N Murase; R G Lee; P Randhawa; A Zeevi; S Pham; R Duquesnoy; J J Fung; T E Starzl
Journal:  Ann Transplant       Date:  1997       Impact factor: 1.530

4.  Pathology of Chronic Rejection: An Overview of Common Findings and Observations About Pathogenic Mechanisms and Possible Prevention.

Authors:  A J Demetris; N Murase; T E Starzl; J J Fung
Journal:  Graft (Georget Tex)       Date:  1998-05

5.  Rejection of combined heart-lung transplants in rats. Function and pathology.

Authors:  J Prop; H D Tazelaar; M E Billingham
Journal:  Am J Pathol       Date:  1987-04       Impact factor: 4.307

Review 6.  Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.

Authors:  T E Starzl; A J Demetris; M Trucco; N Murase; C Ricordi; S Ildstad; H Ramos; S Todo; A Tzakis; J J Fung
Journal:  Hepatology       Date:  1993-06       Impact factor: 17.425

7.  Origin of lymph node-derived lymphocytes in human hepatic allografts.

Authors:  John J Fung; Adriane Zeevi; A Jake Demetris; Thomas E Starzl; Bernd Markus; Kangnian Chen; Marilyn Marrarri; Rene J Duquesnoy
Journal:  Clin Transpl       Date:  1989

8.  An experimental technique for heart-lung transplantation in subprimate models.

Authors:  M P Macris; T Nakatani; T J Myers; D E Lammermeier; S R Igo; O H Frazier; D A Cooley
Journal:  Tex Heart Inst J       Date:  1990
  8 in total

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