Literature DB >> 39138

A nuclear magnetic relaxation study of bound water in solutions of disodium cromoglycate.

S A Attiga, D D Eley, M J Hey.   

Abstract

The amount of water bound to disodium cromoglycate (DSCG) in frozen aqueous solutions was determined from the amplitude of the n.m.r. free induction decay. The hydration number was found to be 15 molecules H2O/molecule DSCG of which 6 H2O molecules were less strongly bound than the rest. Proton T1 and T2 relaxation times in non-frozen solutions implied a values of 10(-8) s for the correlation time of the bound water at 291 K. This is consistent with the mobility of DSCG molecules in a smectic mesophase.

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Year:  1979        PMID: 39138     DOI: 10.1111/j.2042-7158.1979.tb13529.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  1 in total

1.  Oral absorption enhancement of cromolyn sodium through noncovalent complexation.

Authors:  Xuan Ding; Parshuram Rath; Robert Angelo; Thomas Stringfellow; Elizabeth Flanders; Steven Dinh; Isabel Gomez-Orellana; Joseph R Robinson
Journal:  Pharm Res       Date:  2004-12       Impact factor: 4.200

  1 in total

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