Literature DB >> 3913382

Malaria vaccine against sporozoites?

V Nussenzweig, R S Nussenzweig.   

Abstract

Malaria kills over one million people a year. A promising candidate suitable for either a synthetic or a genetically engineered malaria vaccine has been synthesized. The molecule, a string of 4 amino acids repeated 3 times, is modeled on a surface component of sporozoites apparent when they are injected by a mosquito into a human. An immune response to the peptide might neutralize sporozoites before they are sequestered in host liver cells. The peptide reacted with antibodies in serum of randomly selected individuals living where malaria is endemic and with serum from a volunteer protected from infection by immunization with irradiated parasites. It induced antibodies in animals; the antibodies prevented the parasite from entering human cells growing in culture.

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Year:  1985        PMID: 3913382     DOI: 10.1016/s0769-2625(85)80115-x

Source DB:  PubMed          Journal:  Ann Inst Pasteur Immunol (1985)


  3 in total

1.  Developmental changes in the circumsporozoite proteins of Plasmodium berghei and P. gallinaceum in their mosquito vectors.

Authors:  N Boulanger; Y Charoenvit; A Krettli; B Betschart
Journal:  Parasitol Res       Date:  1995       Impact factor: 2.289

2.  Detection of human antibodies against Plasmodium falciparum sporozoites using synthetic peptides.

Authors:  G Del Giudice; A S Verdini; M Pinori; A Pessi; J P Verhave; C Tougne; B Ivanoff; P H Lambert; H D Engers
Journal:  J Clin Microbiol       Date:  1987-01       Impact factor: 5.948

3.  Identification of a neutralizing epitope within minor repeat region of Plasmodium falciparum CS protein.

Authors:  J Mauricio Calvo-Calle; Robert Mitchell; Rita Altszuler; Caroline Othoro; Elizabeth Nardin
Journal:  NPJ Vaccines       Date:  2021-01-18       Impact factor: 7.344

  3 in total

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