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Literature DB >> 391322

Immunological effect of co-trimoxazole on platelets.

F H Claas, J W van der Meer, J Langerak.

Abstract

Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1979 PMID： 391322 PMCID： PMC1596719 DOI： 10.1136/bmj.2.6195.898

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

8 in total

Review 1. Regulation of respiration: (second of three parts).

Authors: A J Berger; R A Mitchell; J W Severinghaus
Journal: N Engl J Med Date: 1977-07-21 Impact factor: 91.245

2. Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.

Authors: R Ferone; J J Burchall; G H Hitchings
Journal: Mol Pharmacol Date: 1969-01 Impact factor: 4.436

3. Trimethoprim, a sulphonamide potentiator.

Authors: S R Bushby; G H Hitchings
Journal: Br J Pharmacol Chemother Date: 1968-05

4. Detection of drug-dependent antibodies by the 51Cr platelet lysis test: documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole.

Authors: P L Cimo; A V Pisciotta; R G Desai; J L Pino; R H Aster
Journal: Am J Hematol Date: 1977 Impact factor: 10.047

8. Immunoreactions involving platelets. IV. Studies on the pathogenesis of thrombocytopenia in drug purpura using test doses of quinidine in sensitized individuals; their implications in idiopathic thrombocytopenic purpura.

Authors: N R SHULMAN
Journal: J Exp Med Date: 1958-05-01 Impact factor: 14.307

8 in total

6 in total

Review 6. Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.

Authors: G P Wormser; G T Keusch; R C Heel
Journal: Drugs Date: 1982-12 Impact factor: 9.546

6 in total

Immunological effect of co-trimoxazole on platelets.

Review 1. Regulation of respiration: (second of three parts).

2. Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.

3. Trimethoprim, a sulphonamide potentiator.

4. Detection of drug-dependent antibodies by the 51Cr platelet lysis test: documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole.

5. Rifampicin-induced immune thrombocytopenia.

6. Sulfamethoxazole-trimethoprim for infections in cancer patients.

7. Co-trimoxazole for prevention of infection in acute leukaemia.

8. Immunoreactions involving platelets. IV. Studies on the pathogenesis of thrombocytopenia in drug purpura using test doses of quinidine in sensitized individuals; their implications in idiopathic thrombocytopenic purpura.

Review 1. Considerations when prescribing trimethoprim-sulfamethoxazole.

Review 2. Drug-induced agranulocytosis: review of possible mechanisms, and prospects for clozapine studies.

3. Drug-induced thrombocytopenia.

Review 4. Hematological side effects of co-trimoxazole.

Review 5. Drug-induced immune thrombocytopenia.

Review 6. Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.