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Literature DB >> 3912187

Cimetidine interaction with amitriptyline.

Abstract

The interaction of cimetidine with amitriptyline was assessed by means of amitriptyline and nortriptyline plasma concentration measurements, standing blood pressure and pulse rate, digit symbol substitution, and visual analogue scales. Cimetidine increased plasma amitriptyline concentrations and decreased plasma nortriptyline concentrations, apparently by inhibiting presystemic metabolism. The changes in blood pressure, pulse rate and digit symbol substitution correlated with changes in concentrations of amitriptyline in plasma and expected changes based on a dose ranging preliminary experiment. Changes in subjective ratings of effects correlated with changes in nortriptyline concentrations in plasma.

Entities: Chemical

Mesh：

Substances：

Year: 1985 PMID： 3912187 DOI： 10.1007/bf00613457

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

20 in total

1. Cimetidine and effect of warfarin.

Authors: B A Wallin; A Jacknowitz; P C Raich
Journal: Ann Intern Med Date: 1979-06 Impact factor: 25.391

2. Cimetidine interaction with phenytoin.

Authors: D J Hetzel; F Bochner; J F Hallpike; D J Shearman; C S Hann
Journal: Br Med J (Clin Res Ed) Date: 1981-05-09

3. Delayed clearance of diazepam due to cimetidine.

Authors: U Klotz; I Reimann
Journal: N Engl J Med Date: 1980-05-01 Impact factor: 91.245

Review 4. Drug interactions with cimetidine.

Authors: A Somogyi; R Gugler
Journal: Clin Pharmacokinet Date: 1982 Jan-Feb Impact factor: 6.447

5. Cimetidine potentiation of the hypoprothrombinemic effect of warfarin.

Authors: B A Silver; W R Bell
Journal: Ann Intern Med Date: 1979-03 Impact factor: 25.391

6. Cimetidine interaction with imipramine and nortriptyline.

Authors: S A Henauer; L E Hollister
Journal: Clin Pharmacol Ther Date: 1984-02 Impact factor: 6.875

7. Cimetidine: interaction with oral anticoagulants in man.

Authors: M J Serlin; R G Sibeon; S Mossman; A M Breckenridge; J R Williams; J L Atwood; J M Willoughby
Journal: Lancet Date: 1979-08-18 Impact factor: 79.321

8. Effects of cimetidine on caffeine disposition in smokers and nonsmokers.

Authors: D C May; C H Jarboe; A B VanBakel; W M Williams
Journal: Clin Pharmacol Ther Date: 1982-05 Impact factor: 6.875

9. Cimetidine increases steady state plasma levels of propranolol.

Authors: I W Reimann; U Klotz; B Siems; J Frölich
Journal: Br J Clin Pharmacol Date: 1981-12 Impact factor: 4.335

10. Cimetidine impairs the elimination of theophylline and antipyrine.

Authors: R K Roberts; J Grice; L Wood; V Petroff; C McGuffie
Journal: Gastroenterology Date: 1981-07 Impact factor: 22.682

11 in total

Review 1. Age-related changes in antidepressant pharmacokinetics and potential drug-drug interactions: a comparison of evidence-based literature and package insert information.

Authors: Richard D Boyce; Steven M Handler; Jordan F Karp; Joseph T Hanlon
Journal: Am J Geriatr Pharmacother Date: 2012-01-27

Cimetidine interaction with amitriptyline.

1. Cimetidine and effect of warfarin.

2. Cimetidine interaction with phenytoin.

3. Delayed clearance of diazepam due to cimetidine.

Review 4. Drug interactions with cimetidine.

5. Cimetidine potentiation of the hypoprothrombinemic effect of warfarin.

6. Cimetidine interaction with imipramine and nortriptyline.

7. Cimetidine: interaction with oral anticoagulants in man.

8. Effects of cimetidine on caffeine disposition in smokers and nonsmokers.

9. Cimetidine increases steady state plasma levels of propranolol.

10. Cimetidine impairs the elimination of theophylline and antipyrine.

Review 1. Age-related changes in antidepressant pharmacokinetics and potential drug-drug interactions: a comparison of evidence-based literature and package insert information.

Review 2. Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).

Review 3. Pharmacokinetic optimisation of tricyclic antidepressant therapy.

Review 4. Ranitidine versus cimetidine. A comparison of their potential to cause clinically important drug interactions.

5. The effect of ranitidine and cimetidine on imipramine disposition.

Review 6. Clinical significance of the cytochrome P450 2C19 genetic polymorphism.

7. Lack of interaction of ranitidine with amitriptyline.

Review 8. Pharmacokinetic interactions of cimetidine 1987.

Review 9. Adverse reactions and interactions with H2-receptor antagonists.

10. A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application.