Literature DB >> 3910544

Oral amoxycillin, an alternative treatment for neurosyphilis.

R E Morrison, S M Harrison, E C Tramont.   

Abstract

A serum amoxycillin concentration of 0.11 g/l was established as being treponemicidal in a rabbit model with orchitis. Seventeen patients treated with amoxycillin 2 g by mouth three times a day plus 500 mg probenecid twice a day attained treponemicidal CSF amoxycillin concentrations. Thus amoxycillin by mouth offers an effective alternative method for treating patients with neurosyphilis.

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Year:  1985        PMID： 3910544      PMCID： PMC1011859          DOI： 10.1136/sti.61.6.359

Source DB:  PubMed          Journal:  Genitourin Med        ISSN： 0266-4348


  8 in total

1.  Simplified, accurate method for antibiotic assay of clinical specimens.

Authors:  J V Bennett; J L Brodie; E J Benner; W M Kirby
Journal:  Appl Microbiol       Date:  1966-03

2.  Treponemicidal levels of amoxicillin in cerebrospinal fluid after oral administration.

Authors:  W R Faber; J D Bos; P J Rietra; H Fass; R V Van Eijk
Journal:  Sex Transm Dis       Date:  1983 Jul-Sep       Impact factor: 2.830

3.  Neurosyphilis: an update.

Authors:  R P Simon
Journal:  West J Med       Date:  1981-01

4.  Failure of penicillin G benzathine in the treatment of neurosyphilis.

Authors:  B M Greene; N R Miller; T E Bynum
Journal:  Arch Intern Med       Date:  1980-08

5.  Amoxicillin entry into human cerebrospinal fluid: comparison with ampicillin.

Authors:  N Clumeck; J P Thys; R Vanhoof; M P Vanderlinden; J P Butzler; E Yourassowsky
Journal:  Antimicrob Agents Chemother       Date:  1978-10       Impact factor: 5.191

6.  Penicillin levels in blood and CSF achieved by treatment of syphilis.

Authors:  E M Dunlop; S S Al-Egaily; E T Houang
Journal:  JAMA       Date:  1979-06-08       Impact factor: 56.272

7.  Neurosyphilis and penicillin levels in cerebrospinal fluid.

Authors:  J A Mohr; W Griffiths; R Jackson; H Saadah; P Bird; J Riddle
Journal:  JAMA       Date:  1976-11-08       Impact factor: 56.272

8.  Meningovascular syphilis after 'appropriate' treatment of primary syphilis.

Authors:  B L Moskovitz; J J Klimek; R L Goldman; N J Fiumara; R Quintiliani
Journal:  Arch Intern Med       Date:  1982-01
  8 in total
  3 in total

Review 1.  Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.

Authors:  A E Singh; B Romanowski
Journal:  Clin Microbiol Rev       Date:  1999-04       Impact factor: 26.132

Review 2.  Management issues in syphilis.

Authors:  David Pao; Beng T Goh; James S Bingham
Journal:  Drugs       Date:  2002       Impact factor: 9.546

3.  Penicillin-binding proteins and peptidoglycan of Treponema pallidum subsp. pallidum.

Authors:  J D Radolf; C Moomaw; C A Slaughter; M V Norgard
Journal:  Infect Immun       Date:  1989-04       Impact factor: 3.441
  3 in total

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