| Literature DB >> 3910352 |
Abstract
One major side effect of administration of gossypol as a male fertility regulating agent is the occurrence of hypokalaemic paralysis. We have reviewed the common causes of hypokalaemia in clinical practice and previous studies of gossypol-induced hypokalaemia in animals and man. The available evidences suggest that gossypol induced renal leakage of potassium. The most likely mechanism is a direct toxic effect of gossypol on the renal tubules.Entities:
Keywords: Animals, Laboratory; Biology; Clinical Research; Contraception; Contraception Research; Contraceptive Agents, Male--side effects; Contraceptive Agents--side effects; Family Planning; Gossypol; Male Contraception; Physiology; Renal Effects; Research Methodology; Urogenital Effects; Urogenital System
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Year: 1985 PMID： 3910352 DOI： 10.1016/0010-7824(85)90047-2
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375