Literature DB >> 3910034

Pharmacology of hirudin: one hundred years after the first report of the anticoagulant agent in medicinal leeches.

F Markwardt.   

Abstract

One hundred years after its discovery hirudin, the selective thrombin inhibitor from medicinal leeches, has been brought into the focus of interest again. Advanced methods of peptide isolation and gene technology are expected to provide the opportunity to obtain pure hirudin in sufficient yield for therapeutic uses. Therefore, the present state of knowledge of this naturally occurring anticoagulant is reported.

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Year:  1985        PMID： 3910034

Source DB:  PubMed          Journal:  Biomed Biochim Acta        ISSN： 0232-766X


  9 in total

1.  Recombinant hirudin, a new anticoagulant, has no effect on faecal blood loss.

Authors:  B H Meyer; H G Luus; F O Muller; P N Badenhorst; M G Lotter; H J Röthig; H Grötsch; B Rosenkranz
Journal:  Br J Clin Pharmacol       Date:  1992-05       Impact factor: 4.335

Review 2.  FXII.

Authors:  G Fuhrer; M J Gallimore; W Heller; H E Hoffmeister
Journal:  Blut       Date:  1990-11

Review 3.  Hirudin, a new therapeutic tool?

Authors:  J Bichler; H Fritz
Journal:  Ann Hematol       Date:  1991-08       Impact factor: 3.673

4.  Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species.

Authors:  M A Lafleur; M D Hollenberg; S J Atkinson; V Knäuper; G Murphy; D R Edwards
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

5.  The use of leeches for treatment of venous congestion of the nipple following breast surgery.

Authors:  M P Gross; J Apesos
Journal:  Aesthetic Plast Surg       Date:  1992       Impact factor: 2.326

6.  The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.

Authors:  G M Clore; D K Sukumaran; M Nilges; J Zarbock; A M Gronenborn
Journal:  EMBO J       Date:  1987-02       Impact factor: 11.598

7.  Rat hepatocytes in serum-free primary culture elaborate an extensive extracellular matrix containing fibrin and fibronectin.

Authors:  S C Stamatoglou; R C Hughes; U Lindahl
Journal:  J Cell Biol       Date:  1987-11       Impact factor: 10.539

8.  Artery-Only Ear Replantation in a Child: A Case Report With Daily Photographic Documentation.

Authors:  Shaun D Mendenhall; Justin D Sawyer; Joshua M Adkinson
Journal:  Eplasty       Date:  2016-12-28

9.  Pharmacokinetics study of recombinant hirudin in the plasma of rats using chromogenic substrate, ELISA, and radioisotope assays.

Authors:  Su-Yun Jiang; Jian Jiao; Ting-Ting Zhang; Yong-Ping Xu
Journal:  PLoS One       Date:  2013-06-13       Impact factor: 3.240
  9 in total

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