Literature DB >> 3908871

The importance of free radicals and catalytic metal ions in human diseases.

B Halliwell, J M Gutteridge.   

Abstract

The study of free radical reactions is not an isolated and esoteric branch of science. A knowledge of free radical chemistry and biochemistry is relevant to an understanding of all diseases and the mode of action of all toxins, if only because diseased or damaged tissues undergo radical reactions more readily than do normal tissues. However it does not follow that because radical reactions can be demonstrated, they are important in any particular instance. We hope that the careful techniques needed to assess the biological role of free radicals will become more widely used.

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Year:  1985        PMID: 3908871     DOI: 10.1016/0098-2997(85)90001-9

Source DB:  PubMed          Journal:  Mol Aspects Med        ISSN: 0098-2997


  126 in total

1.  Regulation of antioxidant enzyme expression by NGF.

Authors:  D Sampath; R Perez-Polo
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

2.  Systemic pattern of free radical generation during coronary bypass surgery.

Authors:  S W Davies; S M Underwood; D G Wickens; R O Feneck; T L Dormandy; R K Walesby
Journal:  Br Heart J       Date:  1990-10

Review 3.  Copper in microbial pathogenesis: meddling with the metal.

Authors:  Marie I Samanovic; Chen Ding; Dennis J Thiele; K Heran Darwin
Journal:  Cell Host Microbe       Date:  2012-02-16       Impact factor: 21.023

Review 4.  Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status.

Authors:  P Merry; P G Winyard; C J Morris; M Grootveld; D R Blake
Journal:  Ann Rheum Dis       Date:  1989-10       Impact factor: 19.103

5.  Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase.

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

6.  Free radical generation by neutrophils: a potential mechanism of cellular injury in acute alcoholic hepatitis.

Authors:  A J Williams; R E Barry
Journal:  Gut       Date:  1987-09       Impact factor: 23.059

7.  The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid.

Authors:  M Wasil; B Halliwell; M Grootveld; C P Moorhouse; D C Hutchison; H Baum
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

8.  The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex.

Authors:  O I Aruoma; B Halliwell; M J Laughton; G J Quinlan; J M Gutteridge
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

9.  Protective effect of seminal plasma proteins on the degradation of ascorbic acid.

Authors:  L Liu; K Dabrowski; A Ciereszko
Journal:  Mol Cell Biochem       Date:  1995-07-05       Impact factor: 3.396

10.  Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence.

Authors:  Chen Ding; Richard A Festa; Ying-Lien Chen; Anna Espart; Òscar Palacios; Jordi Espín; Mercè Capdevila; Sílvia Atrian; Joseph Heitman; Dennis J Thiele
Journal:  Cell Host Microbe       Date:  2013-03-13       Impact factor: 21.023

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