Literature DB >> 3907230

Mathematical modelling of changes in circulating insulin and C-peptide concentrations.

W J Malaisse, Y Scholler.   

Abstract

A simple mathematical model is proposed to assess the validity of methods currently used in clinical investigation to detect short-term or long-term alterations in insulin and/or C-peptide clearance. This model draws attention to unwarranted conclusions which resulted from the analysis of insulin and C-peptide plasma concentrations.

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Year:  1985        PMID： 3907230     DOI： 10.1007/bf02590786

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  4 in total

1.  Oral glucose decreases hepatic extraction of insulin.

Authors:  O M Gibby; C N Hales
Journal:  Br Med J (Clin Res Ed)       Date:  1983-03-19

Review 2.  C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations.

Authors:  K S Polonsky; A H Rubenstein
Journal:  Diabetes       Date:  1984-05       Impact factor: 9.461

3.  C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity.

Authors:  P J Savage; E V Flock; M E Mako; P M Blix; A H Rubenstein; P H Bennett
Journal:  J Clin Endocrinol Metab       Date:  1979-04       Impact factor: 5.958

4.  Hyperinsulinemia of obesity is due to decreased clearance of insulin.

Authors:  M T Meistas; S Margolis; A A Kowarski
Journal:  Am J Physiol       Date:  1983-08
  4 in total

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