Literature DB >> 390711

Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans.

D Baetens, F Malaisse-Lagae, A Perrelet, L Orci.   

Abstract

Three-dimensional reconstructions of islets of Langerhans, based on immunofluorescent staining of successive serial sections with antiserums to insulin, glucagon, somatostatin, and pancreatic polypeptide reveal a marked difference in the number of cells containing glucagon and pancreatic polypeptide depending on the anatomical location of the islet in the pancreas. The two types of islets are situated in regions of exocrine tissue that are drained by different excretory ducts. This demonstration contradicts the assumption that all islets in the pancreas are similar in their endocrine cell content.

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Year:  1979        PMID： 390711     DOI： 10.1126/science.390711

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  65 in total

1.  Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins.

Authors:  P C Guest; E M Bailyes; N G Rutherford; J C Hutton
Journal:  Biochem J       Date:  1991-02-15       Impact factor: 3.857

Review 2.  Lineage determinants in early endocrine development.

Authors:  Sebastian Rieck; Eric D Bankaitis; Christopher V E Wright
Journal:  Semin Cell Dev Biol       Date:  2012-06-21       Impact factor: 7.727

3.  Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration.

Authors:  Claudia Cavelti-Weder; Maria Shtessel; Joshua E Reuss; Agnes Jermendy; Takatsugu Yamada; Francisco Caballero; Susan Bonner-Weir; Gordon C Weir
Journal:  Endocrinology       Date:  2013-09-12       Impact factor: 4.736

4.  Immunohistochemical studies of endocrine cells in heterotopic pancreas.

Authors:  M Hara; Y Tsutsumi
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

5.  Low insulin content of large islet population is present in situ and in isolated islets.

Authors:  Han-Hung Huang; Lesya Novikova; S Janette Williams; Irina V Smirnova; Lisa Stehno-Bittel
Journal:  Islets       Date:  2011 Jan-Feb       Impact factor: 2.694

6.  Single Cell Peptide Heterogeneity of Rat Islets of Langerhans.

Authors:  Erik T Jansson; Troy J Comi; Stanislav S Rubakhin; Jonathan V Sweedler
Journal:  ACS Chem Biol       Date:  2016-07-29       Impact factor: 5.100

7.  Effects of glucose and glucagon on the fructose 2,6-bisphosphate content of pancreatic islets and purified pancreatic B-cells. A comparison with isolated hepatocytes.

Authors:  A Sener; E Van Schaftingen; M Van de Winkel; D G Pipeleers; F Malaisse-Lagae; W J Malaisse; H G Hers
Journal:  Biochem J       Date:  1984-08-01       Impact factor: 3.857

8.  Snapshot Hyperspectral Light-Sheet Imaging of Signal Transduction in Live Pancreatic Islets.

Authors:  Zeno Lavagnino; Jason Dwight; Alessandro Ustione; Thuc-Uyen Nguyen; Tomasz S Tkaczyk; David W Piston
Journal:  Biophys J       Date:  2016-07-26       Impact factor: 4.033

9.  Coexistence of pancreatic polypeptide (PP)-and glucagon-immunoreactivity in pancreatic endocrine cells of mouse.

Authors:  J H Rombout; M E Abad; F M Binkhorst; J J Taverne-Thiele
Journal:  Histochemistry       Date:  1987

Review 10.  Pancreatic glucagonoma with and without syndrome. Immunocytochemical study of 5 tumour cases and review of the literature.

Authors:  E Ruttman; G Klöppel; G Bommer; M Kiehn; P U Heitz
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1980
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