Literature DB >> 3906420

Mechanisms of leu-enkephalin hydrolysis in human plasma.

G Roscetti, R Possenti, E Bassano, L G Roda.   

Abstract

The present work describes the kinetics of enkephalin hydrolysis by plasma enzymes and the fragmentation pattern of both the parent peptide and of the first hydrolysis by-products. The degradation kinetics were followed by positive identification of the hydrolysis fragments by chromatographic methods, by amino acid analysis and by scintillation counting of tritium-labeled enkephalin. In addition, the results presented confirm the role of the low molecular weight plasma components in the control of the hydrolysis of the peripherally-released enkephalins.

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Year:  1985        PMID： 3906420     DOI： 10.1007/bf00964980

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  22 in total

1.  Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates.

Authors:  J M Hambrook; B A Morgan; M J Rance; C F Smith
Journal:  Nature       Date:  1976-08-26       Impact factor: 49.962

2.  Extremely rapid degradation of [3H] methionine-enkephalin by various rat tissues in vivo and in vitro.

Authors:  A Dupont; L Cusan; M Garon; G Alvarado-Urbina; F Labrie
Journal:  Life Sci       Date:  1977-10-01       Impact factor: 5.037

3.  Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines.

Authors:  O H Viveros; E J Diliberto; E Hazum; K J Chang
Journal:  Mol Pharmacol       Date:  1979-11       Impact factor: 4.436

Review 4.  Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase ("enkephalinase") as neuropeptidase.

Authors:  J C Schwartz; B Malfroy; S De La Baume
Journal:  Life Sci       Date:  1981-10-26       Impact factor: 5.037

5.  The metabolic disposition of radiolabeled enkephalins in vitro and in situ.

Authors:  F B Craves; P Y Law; C A Hunt; H H Loh
Journal:  J Pharmacol Exp Ther       Date:  1978-08       Impact factor: 4.030

6.  Met-enkephalin circulates in human plasma.

Authors:  V Clement-Jones; P J Lowry; L H Rees; G M Besser
Journal:  Nature       Date:  1980-01-17       Impact factor: 49.962

7.  Purification and substrate characterization of a human enkephalin-degrading aminopeptidase.

Authors:  M A Coletti-Previero; H Mattras; B Descomps; A Previero
Journal:  Biochim Biophys Acta       Date:  1981-01-15

8.  Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells.

Authors:  B G Livett; D M Dean; L G Whelan; S Udenfriend; J Rossier
Journal:  Nature       Date:  1981-01-22       Impact factor: 49.962

9.  An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.

Authors:  R V Lewis; A S Stern; S Kimura; J Rossier; S Stein; S Udenfriend
Journal:  Science       Date:  1980-06-27       Impact factor: 47.728

10.  Met-enkephalin immunoreactivity in blood platelets.

Authors:  A M Di Giulio; G B Picotti; A M Cesura; A E Panerai; P Mantegazza
Journal:  Life Sci       Date:  1982-05-10       Impact factor: 5.037
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  8 in total

1.  Different effects of steroidal therapy on neuropeptide-active enzymes in male and female human saliva.

Authors:  Federica Albo; Riccardo Antonangeli; Antonella Cavazza; Mario Marini; L Giorgio Roda; Paolo Rossi
Journal:  Neurochem Res       Date:  2002-09       Impact factor: 3.996

2.  Plasma beta endorphin in cirrhosis and renal failure.

Authors:  J R Thornton; M S Losowsky
Journal:  Gut       Date:  1991-03       Impact factor: 23.059

3.  Role of enzymes and inhibitors in leu-enkephalin metabolism in rabbit and human plasma.

Authors:  F Bolacchi; M Marini; A Urbani; L Bongiorno; L G Roda
Journal:  Neurochem Res       Date:  1996-08       Impact factor: 3.996

4.  Plasma leucine enkephalin is increased in liver disease.

Authors:  J R Thornton; M S Losowsky
Journal:  Gut       Date:  1989-10       Impact factor: 23.059

5.  Enkephalin binding systems in human plasma. III: Comparative protection of different peptides.

Authors:  G Roscetti; F Venturelli; L G Roda
Journal:  Neurochem Res       Date:  1988-03       Impact factor: 3.996

6.  Is ascites caused by impaired hepatic inactivation of blood borne endogenous opioid peptides?

Authors:  J R Thornton; H Dean; M S Losowsky
Journal:  Gut       Date:  1988-09       Impact factor: 23.059

7.  Enzymes and inhibitors in leu-enkephalin in metabolism in human plasma.

Authors:  F Bolacchi; M Marini; A Urbani; L G Roda
Journal:  Neurochem Res       Date:  1995-09       Impact factor: 3.996

8.  An Effective and Safe Enkephalin Analog for Antinociception.

Authors:  K K DurgaRao Viswanadham; Roland Böttger; Lukas Hohenwarter; Anne Nguyen; Elham Rouhollahi; Alexander Smith; Yi-Hsuan Tsai; Yuan-Yu Chang; Christopher Llynard Ortiz; Lee-Wei Yang; Liliana Jimenez; Siyuan Li; Chan Hur; Shyh-Dar Li
Journal:  Pharmaceutics       Date:  2021-06-22       Impact factor: 6.321
  8 in total

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