Literature DB >> 3905607

Unimpaired function of human phagocytes in the presence of phagocytosis-resistant group A streptococci.

B N Manjula, M L Schmidt, V A Fischetti.   

Abstract

The resistance to phagocytosis of the group A streptococci has been attributed mainly to the presence of the surface antigen, M protein. In the present study, we addressed the question of whether the phagocytosis resistance of the group A streptococci is due to their ability to impair the function of the phagocytic cells. The results of these studies demonstrate that the presence of a large excess of a phagocytosis-resistant strain of streptococci does not significantly interfere with either the antibody-independent or the antibody-dependent phagocytosis of streptococci. Apparently, a phagocytosis-resistant strain of streptococci does not bring about a generalized deactivation of the phagocytic plasma membrane. This suggests that if the resistance of the group A streptococci is due to any deactivating influence at all on the phagocytic plasma membrane, it is likely to be confined to the contact area of the cocci with the phagocyte.

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Year:  1985        PMID： 3905607      PMCID： PMC261121          DOI： 10.1128/iai.50.3.610-613.1985

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  17 in total

1.  Alternate complement pathway activation by group A streptococci: role of M-protein.

Authors:  A L Bisno
Journal:  Infect Immun       Date:  1979-12       Impact factor: 3.441

2.  SELECTION OF GROUP A STREPTOCOCCI RICH IN M-PROTEIN FROM POPULATIONS POOR IN M-PROTEIN.

Authors:  C G BECKER
Journal:  Am J Pathol       Date:  1964-01       Impact factor: 4.307

3.  Presence of two distinct regions in the coiled-coil structure of the streptococcal Pep M5 protein: relationship to mammalian coiled-coil proteins and implications to its biological properties.

Authors:  B N Manjula; B L Trus; V A Fischetti
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

4.  Resistance to phagocytosis by group A streptococci: failure of deposited complement opsonins to interact with cellular receptors.

Authors:  J J Weis; S K Law; R P Levine; P P Cleary
Journal:  J Immunol       Date:  1985-01       Impact factor: 5.422

5.  Common protective antigens of group A streptococcal M proteins masked by fibrinogen.

Authors:  E Whitnack; J B Dale; E H Beachey
Journal:  J Exp Med       Date:  1984-04-01       Impact factor: 14.307

6.  Electron microscopic studies on streptococci. I. M antigen.

Authors:  J Swanson; K C Hsu; E C Gotschlich
Journal:  J Exp Med       Date:  1969-11-01       Impact factor: 14.307

7.  Tropomyosin-like seven residue periodicity in three immunologically distinct streptococal M proteins and its implications for the antiphagocytic property of the molecule.

Authors:  B N Manjula; V A Fischetti
Journal:  J Exp Med       Date:  1980-03-01       Impact factor: 14.307

8.  Persistence of type-specific antibodies in man following infection with group A streptococci.

Authors:  R C LANCEFIELD
Journal:  J Exp Med       Date:  1959-08-01       Impact factor: 14.307

9.  The ability of group A streptococci killed by heat or mercury arc irradiation to resist ingestion by phagocytes.

Authors:  G G WILEY; A T WILSON
Journal:  J Exp Med       Date:  1956-01-01       Impact factor: 14.307

10.  Streptococcal M6 protein expressed in Escherichia coli. Localization, purification, and comparison with streptococcal-derived M protein.

Authors:  V A Fischetti; K F Jones; B N Manjula; J R Scott
Journal:  J Exp Med       Date:  1984-04-01       Impact factor: 14.307
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  10 in total

1.  The amino-terminal region of group A streptococcal M protein determines its molecular state of assembly and function.

Authors:  K M Khandke; T Fairwell; E H Braswell; B N Manjula
Journal:  J Protein Chem       Date:  1991-02

Review 2.  Molecular aspects of the phagocytosis resistance of group A streptococci.

Authors:  B N Manjula
Journal:  Eur J Epidemiol       Date:  1988-09       Impact factor: 8.082

3.  Expression of M type 12 protein by a group A streptococcus exhibits phaselike variation: evidence for coregulation of colony opacity determinants and M protein.

Authors:  W J Simpson; P P Cleary
Journal:  Infect Immun       Date:  1987-10       Impact factor: 3.441

Review 4.  Streptococcal M protein: molecular design and biological behavior.

Authors:  V A Fischetti
Journal:  Clin Microbiol Rev       Date:  1989-07       Impact factor: 26.132

5.  Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H.

Authors:  R D Horstmann; H J Sievertsen; J Knobloch; V A Fischetti
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

6.  Localization by site-directed mutagenesis of the site in human complement factor H that binds to Streptococcus pyogenes M protein.

Authors:  A K Sharma; M K Pangburn
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

7.  Group A streptococci bind to mucin and human pharyngeal cells through sialic acid-containing receptors.

Authors:  P A Ryan; V Pancholi; V A Fischetti
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

8.  Role of fibrinogen in complement inhibition by streptococcal M protein.

Authors:  R D Horstmann; H J Sievertsen; M Leippe; V A Fischetti
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

9.  Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization.

Authors:  D Medaglini; G Pozzi; T P King; V A Fischetti
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

10.  Difference in the structural features of streptococcal M proteins from nephritogenic and rheumatogenic serotypes.

Authors:  K M Khandke; T Fairwell; B N Manjula
Journal:  J Exp Med       Date:  1987-07-01       Impact factor: 14.307
  10 in total

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