Chronic alcoholism in males: cognitive deficit as a function of age of onset, age, and duration.

Performance on a cognitive rule-learning task was studied in detoxified alcoholics having early/late onset and short-/long-term drinking histories, and in matched nonalcoholic controls. There were pronounced cognitive deficits in early onset and long-term alcoholics. Impairment was severest in the early onset group, even though they were on the average 15 years younger than the late onset group. Early onset alcoholics were relatively more impaired on both the abstract and the verbal Shipley measures. This group also manifested a relative deficit in ability to show positive transfer across problems. Chronicity of alcoholism also interfered with acquisition of an abstract relationship between concrete stimulus attributes. Age negatively influenced ability to perform abstractions, but not commonly tested verbal skills. The findings suggest that an early onset of alcoholism, regardless of duration of problem drinking, is particularly predictive of cognitive impairment.