Literature DB >> 3904451

Low cyclosporin A blood levels and acute graft rejection in a renal transplant recipient during rifampin treatment.

G Offermann, F Keller, M Molzahn.   

Abstract

Cyclosporin A trough blood levels were unusually low during rifampin treatment in a kidney transplant patient. Simultaneously, acute graft rejection occurred. Pharmacokinetic investigation revealed a rapid turnover of cyclosporin A leading to low blood levels. Cessation of rifampin therapy reversed these changes. Rifampin substantially reduces the bioavailability of cyclosporin A and should not be used in transplant recipients on cyclosporin A.

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Year:  1985        PMID： 3904451     DOI： 10.1159/000166968

Source DB:  PubMed          Journal:  Am J Nephrol        ISSN： 0250-8095            Impact factor:   3.754


  10 in total

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Review 9.  Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) System.

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  10 in total

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