Literature DB >> 390391

Mutational studies with diquat and paraquat in vitro.

R Benigni, M Bignami, A Carere, G Conti, L Conti, R Crebelli, E Dogliotti, G Gualandi, A Novelletto, V A Ortali.   

Abstract

Diquat and paraquat were assayed in the following tests. (1) Ames test in Salmonella typhimurium (strains TA1535, TA1537, TA1538, TA98 and TA100) with and without rat-liver microsomal fractions. (2) Resistance to 8-azaguanine in Salmonella typhimurium (strain hisG46, TA92 and TA1535. (3) Repair test in Salmonella typhimurium (strains TA1538 and TA1978). (4) Gene mutations in Aspergillus nidulans: 8-AG resistance and methionine suppression (meth A1 locus). (5) Lethal recessive damage in Aspergillus nidulans. (6) Unscheduled DNA synthesis (UDS) in human epithelial-like cells (EUE). Diquat and paraquat were positive in S. typhimurium (in the repair test and the 8-AG resistance system), in A. nidulans (for gene mutations and lethal recessive damage induction) and in EUE cells (UDS induction).

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Year:  1979        PMID: 390391     DOI: 10.1016/0165-1218(79)90148-4

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  1 in total

1.  Determination of genotoxicity of the metabolites of the pesticides Guthion, Sencor, Lorox, Reglone, Daconil and Admire by 32P-postlabeling.

Authors:  R G Shah; J Lagueux; S Kapur; P Levallois; P Ayotte; M Tremblay; J Zee; G G Poirier
Journal:  Mol Cell Biochem       Date:  1997-04       Impact factor: 3.396

  1 in total

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