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Literature DB >> 3903518

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors.

G Keller, C Paige, E Gilboa, E F Wagner.

Abstract

Bone marrow cells infected with retroviral vectors carrying the bacterial neomycin resistance (neo) gene as a marker were used for long-term reconstitution of the haematopoietic system of irradiated mice. The neo gene is expressed in the myeloid and lymphoid lineages of these animals and an analysis of the sites of viral integration indicates that these lineages are derived from the same primitive multipotent cells.

Entities: Chemical Species

Mesh：

Substances：
Genetic Markers
Neomycin

Year: 1985 PMID： 3903518 DOI： 10.1038/318149a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

146 in total

1. Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the IgG scaffold is important for induction and maintenance of immune hyporesponsiveness.

Authors: Y Kang; M Melo; E Deng; R Tisch; M El-Amine; D W Scott
Journal: Proc Natl Acad Sci U S A Date: 1999-07-20 Impact factor: 11.205

2. High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

Authors: M Cotten; E Wagner; K Zatloukal; S Phillips; D T Curiel; M L Birnstiel
Journal: Proc Natl Acad Sci U S A Date: 1992-07-01 Impact factor: 11.205

3. Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.

Authors: C C Fraser; S J Szilvassy; C J Eaves; R K Humphries
Journal: Proc Natl Acad Sci U S A Date: 1992-03-01 Impact factor: 11.205

4. A new retrovirus packaging cell for gene transfer constructed from amplified long terminal repeat-free chimeric proviral genes.

Authors: Y Takahara; K Hamada; D E Housman
Journal: J Virol Date: 1992-06 Impact factor: 5.103

10. A nonproducer, interfering human immunodeficiency virus (HIV) type 1 provirus can be transduced through a murine leukemia virus-based retroviral vector: recovery of an anti-HIV mouse/human pseudotype retrovirus.

Authors: M Federico; F Nappi; G Ferrari; C Chelucci; F Mavilio; P Verani
Journal: J Virol Date: 1995-11 Impact factor: 5.103

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors.

1. Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the IgG scaffold is important for induction and maintenance of immune hyporesponsiveness.

2. High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

3. Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.

4. A new retrovirus packaging cell for gene transfer constructed from amplified long terminal repeat-free chimeric proviral genes.

Review 5. An evolving model of hematopoietic stem cell functional identity.

6. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

7. High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones.

Review 8. Mapping the life histories of T cells.

9. Not a split decision for human hematopoiesis.

10. A nonproducer, interfering human immunodeficiency virus (HIV) type 1 provirus can be transduced through a murine leukemia virus-based retroviral vector: recovery of an anti-HIV mouse/human pseudotype retrovirus.