| Literature DB >> 3901799 |
Abstract
The present paper describes a rat strain, Maudsley reactive (MR/N), which dramatically and reliably shows enhanced locomotor stimulation in an openfield apparatus after low doses of ethanol. Other strains, Sprague-Dawley and Wistar inbred, do not show stimulation, whereas Maudsley nonreactive rats show a less dramatic and variable response to ethanol, compared to the MR/N strain. Female MR/N rats show greater stimulation than male MR/N rats, and the response is dose-, age-, and apparatus-related. We conclude that low dose ethanol-induced locomotor stimulation in the MR/N rat strain could be a valuable rodent model for studying central neurochemical correlates of alcohol intoxication.Entities:
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Year: 1985 PMID： 3901799 DOI： 10.1111/j.1530-0277.1985.tb05550.x
Source DB: PubMed Journal: Alcohol Clin Exp Res ISSN： 0145-6008 Impact factor: 3.455