Literature DB >> 390133

Mode of action of delta-9-tetrahydrocannabinol on hypothalamo-pituitary function in adult female rats.

I Chakravarty, P G Shah, A R Sheth, J J Ghosh.   

Abstract

Administration of delta-9-tetrahydrocannabinol (delta 9-THC) to pro-oestrous rats (5 mg/kg and 10 mg/kg, i.p. for 10 days) decreased the hypothalamic LH-RH content. Serum prolactin levels were reduced but serum LH and FSH and pituitary hormone content were similar to values in dioestrous rats. It is suggested that delta 9-THC acts primarily on the hypothalamus.

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Year:  1979        PMID: 390133     DOI: 10.1530/jrf.0.0570113

Source DB:  PubMed          Journal:  J Reprod Fertil        ISSN: 0022-4251


  3 in total

1.  Regulation of gonadotropin-releasing hormone secretion by cannabinoids.

Authors:  C Michael Gammon; G Mark Freeman; Weihua Xie; Wihua Xie; Sandra L Petersen; William C Wetsel
Journal:  Endocrinology       Date:  2005-07-14       Impact factor: 4.736

2.  The effect of delta 1tetrahydrocannabinol on luteinizing hormone release in castrated and hypothalamic deafferented male rats.

Authors:  M Puder; I Nir; R A Siegel; J Weidenfeld; D Ayalon
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

Review 3.  Cannabis and Cannabinoids in Reproduction and Fertility: Where We Stand.

Authors:  Bruno M Fonseca; Irene Rebelo
Journal:  Reprod Sci       Date:  2021-05-10       Impact factor: 2.924

  3 in total

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