Literature DB >> 3899918

Serum IL-2 inhibitor in mice. I. Increase during infection.

R Lelchuk, J H Playfair.   

Abstract

Serum from normal mice contains an inhibitor of interleukin-2 (IL-2) which probably interacts directly with IL-2. Athymic mice and normal mice kept under specific pathogen-free conditions do not show this activity, whereas mice infected with malaria parasites have increased serum levels of inhibitor. This IL-2 inhibitor may play an important part in regulating T-cell function.

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Year:  1985        PMID: 3899918      PMCID: PMC1453670     

Source DB:  PubMed          Journal:  Immunology        ISSN: 0019-2805            Impact factor:   7.397


  14 in total

1.  T-cell activation in murine malaria.

Authors:  A N Jayawardena; G A Targett; E Leuchars; R L Carter; M J Doenhoff; A J Davies
Journal:  Nature       Date:  1975-11-13       Impact factor: 49.962

2.  Effect of normal mouse serum on mouse lymphocyte transformation in vitro.

Authors:  D S Nelson; C N Shneider
Journal:  Eur J Immunol       Date:  1974-02       Impact factor: 5.532

3.  Nonspecific inhibitor released by T acceptor cells reduces the production of interleukin-2.

Authors:  M Malkovsky; G L Asherson; B Stockinger; M C Watkins
Journal:  Nature       Date:  1982-12-16       Impact factor: 49.962

Review 4.  Malaria and alterations in immune reactivity.

Authors:  W P Weidanz
Journal:  Br Med Bull       Date:  1982-05       Impact factor: 4.291

5.  Cell-mediated immunity in mice vaccinated against malaria.

Authors:  B J Cottrell; J H Playfair; B J De Souza
Journal:  Clin Exp Immunol       Date:  1978-11       Impact factor: 4.330

6.  Anti-lymphocyte antibodies in lethal mouse malaria. II. Induction of an autoantibody specific suppressor T cell by non-lethal P. yoelii.

Authors:  J B de Souza; J H Playfair
Journal:  Clin Exp Immunol       Date:  1983-10       Impact factor: 4.330

7.  Modification of T-cell proliferation and interleukin 2 production in mice infected with Trypanosoma cruzi.

Authors:  A Harel-Bellan; M Joskowicz; D Fradelizi; H Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

8.  In vivo development of cytolytic T lymphocytes (CTL) to hapten-altered self: MIs-disparate cells facilitate the response by neutralizing IL 2 inhibitor.

Authors:  S C Gautam; M L Hilfiker; J R Battisto
Journal:  J Immunol       Date:  1983-02       Impact factor: 5.422

9.  Differential involvement of non-specific suppressor T cells in two lethal murine malaria infections.

Authors:  R Lelchuk; V M Sprott; J H Playfair
Journal:  Clin Exp Immunol       Date:  1981-08       Impact factor: 4.330

10.  Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo.

Authors:  C Hardt; M Röllinghoff; K Pfizenmaier; H Mosmann; H Wagner
Journal:  J Exp Med       Date:  1981-08-01       Impact factor: 14.307

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  20 in total

Review 1.  The role of pharmacokinetics in the development of biotechnologically derived agents.

Authors:  R J Wills; B L Ferraiolo
Journal:  Clin Pharmacokinet       Date:  1992-12       Impact factor: 6.447

Review 2.  Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins.

Authors:  Iftekhar Mahmood; Martin D Green
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

Review 3.  The relevance of pharmacokinetics in the development of biotechnology products.

Authors:  S Toon
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1996 Apr-Jun       Impact factor: 2.441

Review 4.  Roles of interferon produced in physiological conditions. A speculative review.

Authors:  V Bocci
Journal:  Immunology       Date:  1988-05       Impact factor: 7.397

5.  Helper and suppressor activities of an autoreactive mouse thyroglobulin-specific T-cell clone.

Authors:  B R Champion; P Hutchings; S Davies; S Marshall-Clarke; A Cooke; I M Roitt
Journal:  Immunology       Date:  1986-05       Impact factor: 7.397

Review 6.  Interactions of viruses with the immune system.

Authors:  C A Mims
Journal:  Clin Exp Immunol       Date:  1986-10       Impact factor: 4.330

7.  Serum IL-2 inhibitor in mice. II. Molecular characteristics.

Authors:  D Male; R Lelchuk; S Curry; G Pryce; J H Playfair
Journal:  Immunology       Date:  1985-09       Impact factor: 7.397

8.  Interleukin 2 inhibitor in synovial fluid.

Authors:  P Emery; K C Gentry; A Kelso; I R Mackay
Journal:  Clin Exp Immunol       Date:  1988-04       Impact factor: 4.330

9.  Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders.

Authors:  J Y Djeu; T Kasahara; J E Balow; G C Tsokos
Journal:  Clin Exp Immunol       Date:  1986-08       Impact factor: 4.330

10.  Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria.

Authors:  P H Jakobsen; S Morris-Jones; T G Theander; L Hviid; M B Hansen; K Bendtzen; R G Ridley; B M Greenwood
Journal:  Clin Exp Immunol       Date:  1994-04       Impact factor: 4.330

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