Literature DB >> 3899821

Appearance of a functional insulin receptor during rabbit embryogenesis.

J F Peyron, M Samson, E Van Obberghen, D Brandenburg, M Fehlmann.   

Abstract

The domain structure of the insulin receptor was investigated in liver and brown adipose tissue of developing rabbits. The structure of the binding domain (alpha-subunit) was analysed after covalent labelling with a 125I photo-reactive insulin analogue. The structure of the tyrosine kinase domain (beta-subunit) and the transmission of the hormonal signal from the alpha-to the beta-subunit were analysed by stimulating with insulin the autophosphorylation of the beta-subunit. Finally, the immunoreactivity of the receptor in developing tissues was assessed with anti-receptor antibodies. The results show that a functional insulin receptor can be detected at the early stages of fetal development in both tissues and is conserved throughout ontogenesis to adulthood.

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Year:  1985        PMID： 3899821     DOI： 10.1007/bf00283146

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  22 in total

1.  Development of insulin and glucagon binding and the adenylate cyclase response in liver membranes of the prenatal, postnatal, and adult rat: evidence of glucagon "resistance".

Authors:  E Blazquez; B Rubalcava; R Montesano; L Orci; R H Unger
Journal:  Endocrinology       Date:  1976-04       Impact factor: 4.736

2.  Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase.

Authors:  J L Sadoul; J F Peyron; R Ballotti; A Debant; M Fehlmann; E Van Obberghen
Journal:  Biochem J       Date:  1985-05-01       Impact factor: 3.857

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Photoreactive insulin analogues used to characterise the insulin receptor.

Authors:  M H Wisher; M D Baron; R H Jones; P H Sönksen
Journal:  Biochem Biophys Res Commun       Date:  1980-01-29       Impact factor: 3.575

5.  Characterization of the hepatic receptor for insulin in the perinatal rat.

Authors:  F Vinicor; L Kiedrowski
Journal:  Endocrinology       Date:  1982-03       Impact factor: 4.736

6.  The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

Authors:  P F Pilch; M P Czech
Journal:  J Biol Chem       Date:  1980-02-25       Impact factor: 5.157

7.  Glucocorticoids and hypothyroidism modulate development of fetal lung insulin receptors.

Authors:  S U Devaskar; S Ganguli; U P Devaskar; M A Sperling
Journal:  Am J Physiol       Date:  1982-06

8.  Role of insulin in the growth of fetal rat tissues.

Authors:  P S Cooke; C S Nicoll
Journal:  Endocrinology       Date:  1984-02       Impact factor: 4.736

9.  Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase.

Authors:  E Van Obberghen; B Rossi; A Kowalski; H Gazzano; G Ponzio
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

10.  Photoaffinity labelling of the insulin receptor in intact rat hepatocytes, mouse soleus muscle, and cultured human lymphocytes.

Authors:  M Fehlmann; Y Le Marchand-Brustel; E Van Obberghen; D Brandenburg; P Freychet
Journal:  Diabetologia       Date:  1982-11       Impact factor: 10.122
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  2 in total

1.  A distinctive family of embryonic protein-tyrosine kinase receptors.

Authors:  E B Pasquale
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

2.  Tyrosine phosphorylated proteins in different tissues during chick embryo development.

Authors:  P A Maher; E B Pasquale
Journal:  J Cell Biol       Date:  1988-05       Impact factor: 10.539
  2 in total

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