Literature DB >> 3899712

Immunocytochemical demonstration of calmodulin in cells secreting by exocytosis.

C Egsmose, E Bock, K Møllgård, N A Thorn.   

Abstract

Calmodulin is a regulator of several calcium-dependent cellular processes. It has been suggested that it plays a role in the mechanism of secretion. Employing an indirect immunoperoxidase technique at the light microscope level, this study demonstrates the presence of calmodulin in several exocytotic cells (mast cells, thyroid follicular cells, neurohypophyseal neurosecretory terminals, pancreatic beta-cells and pancreatic acinus cells) in rat and man. The positive staining reaction for calmodulin was granular and at least in the case of rat mast cells it appeared to be associated with the granule membrane.

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Year:  1985        PMID： 3899712     DOI： 10.1007/bf01952085

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Presence and possible role of calcium-dependent regulator (calmodulin) in rat islets of Langerhans.

Authors:  M C Sugden; M R Christie; S J Ashcroft
Journal:  FEBS Lett       Date:  1979-09-01       Impact factor: 4.124

Review 2.  Calcium and neurosecretion.

Authors:  N A Thorn; J T Russell; C Torp-Pedersen; M Treiman
Journal:  Ann N Y Acad Sci       Date:  1978-04-28       Impact factor: 5.691

3.  Effect of divalent cations and metabolic energy on the anaphylactic histamine release from rat peritoneal mast cells.

Authors:  B Diamant; N Grosman; P Stahl Skov; S Thomle
Journal:  Int Arch Allergy Appl Immunol       Date:  1974

4.  Calmodulin and neurosecretion.

Authors:  R M Sheaves; D B Hope
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

5.  Production of a high affinity antibody specific to the calcium-free-form of calmodulin, using N-acetyl-muramyl-L-alanyl-D-isoglutamine-calmodulin conjugate.

Authors:  J Slaninová; N A Thorn
Journal:  J Immunoassay       Date:  1983

6.  Calmodulin: an overview.

Authors:  W Y Cheung
Journal:  Fed Proc       Date:  1982-05

Review 7.  Calcium as intracellular messenger: sensitivity modulation, C-kinase pathway, and sustained cellular response.

Authors:  H Rasmussen; I Kojima; K Kojima; W Zawalich; W Apfeldorf
Journal:  Adv Cyclic Nucleotide Protein Phosphorylation Res       Date:  1984

8.  Structural similarities between the Ca2+-dependent regulatory proteins of 3':5'-cyclic nucleotide phosphodiesterase and actomyosin ATPase.

Authors:  D M Watterson; W G Harrelson; P M Keller; F Sharief; T C Vanaman
Journal:  J Biol Chem       Date:  1976-08-10       Impact factor: 5.157

9.  Calmodulin binding to secretory granules isolated from bovine neurohypophyses.

Authors:  S F Olsen; J Slaninova; M Treiman; T Saermark; N A Thorn
Journal:  Acta Physiol Scand       Date:  1983-08

10.  Calmodulin and calmodulin-binding proteins in canine pancreas.

Authors:  D C Bartelt; G A Scheele
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691
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