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Literature DB >> 3899662

Pharmacokinetics and metabolism of vincamine and related compounds.

Abstract

The pharmacokinetics and metabolism of vincamine, vinpocetine, methylene-methoxy-apovincaminic acid ester and eburnamine have been reviewed. The main route of elimination for vincamine, vinpocetine and methylene-methoxy-apovincaminic acid ester is ester cleavage and conjugation in the case of eburnamine. Vincamine and its derivatives show significant differences in metabolic pathway and their elimination is rapid in the species studied. Emphasis has been placed on the analytical methods used for monitoring these drugs in biological systems.

Entities: Chemical

Mesh：

Substances：

Year: 1985 PMID： 3899662 DOI： 10.1007/BF03189702

Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.441

44 in total

1. Pharmacokinetic data on tritium labelled ethyl apovincaminate.

Authors: L Vereczkey; G Zólyomi; L Szporny
Journal: Arzneimittelforschung Date: 1976

2. The depleting effect of vincamin on the cerebral serotonin level.

Authors: P GOROG; L SZPORNY
Journal: Biochem Pharmacol Date: 1962-02 Impact factor: 5.858

3. [On the pharmacokinetics of vincamine after i.v. and oral application to the dog (author's transl)].

Authors: H Laufen; W Juhran; W Fleissig; R Götz; F Scharpf; G Bartsch
Journal: Arzneimittelforschung Date: 1977

4. Gas chromatographic method for the determination of vincamine in blood.

Authors: H Kinsun; M A Moulin
Journal: J Chromatogr Date: 1977-11-21

5. [Treatment of cerebrovascular insufficiency. A double blind trial of Cetal retard against cinnarizine (author's transl)].

Authors: H Bartels
Journal: MMW Munch Med Wochenschr Date: 1977-10-28

3. Systemic exposure of vinpocetine in pregnant Sprague Dawley rats following repeated oral exposure: An investigation of fetal transfer.

Authors: Suramya Waidyanatha; Heather Toy; Natalie South; Seth Gibbs; Esra Mutlu; Brian Burback; Barry S McIntyre; Natasha Catlin
Journal: Toxicol Appl Pharmacol Date: 2017-11-15 Impact factor: 4.219

4. Updates of Recent Vinpocetine Research in Treating Cardiovascular Diseases.

Authors: Chongyang Zhang; Chen Yan
Journal: J Cell Immunol Date: 2020

4 in total

Pharmacokinetics and metabolism of vincamine and related compounds.

1. Pharmacokinetic data on tritium labelled ethyl apovincaminate.

2. The depleting effect of vincamin on the cerebral serotonin level.

3. [On the pharmacokinetics of vincamine after i.v. and oral application to the dog (author's transl)].

4. Gas chromatographic method for the determination of vincamine in blood.

5. [Treatment of cerebrovascular insufficiency. A double blind trial of Cetal retard against cinnarizine (author's transl)].

Review 6. [A new therapeutic indication for the alkaloids of the periwinkle].

7. [Pharmacokinetics of multilayer vincamine dragees. Study of normal subjects].

8. [Fluorescence assay and pharmacokinetics of vincamine in rats (author's transl)].

9. [Kinetic behavior of 3H-vincamine in man. Compartmental analysis].

10. Metabolism of vincamine in the rat in vivo and in vitro.

1. Therapeutic utility of phosphodiesterase type I inhibitors in neurological conditions.

2. Study on the absorption of vinpocetine and apovincaminic acid.

3. Systemic exposure of vinpocetine in pregnant Sprague Dawley rats following repeated oral exposure: An investigation of fetal transfer.

4. Updates of Recent Vinpocetine Research in Treating Cardiovascular Diseases.