| Literature DB >> 389892 |
R Buffa, O Crivelli, R Fiocca, P Fontana, E Solcia.
Abstract
Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes.Entities:
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Year: 1979 PMID: 389892 DOI: 10.1007/bf00508008
Source DB: PubMed Journal: Histochemistry ISSN: 0301-5564