Literature DB >> 3898362

Spatially regulated expression of homeotic genes in Drosophila.

K Harding, C Wedeen, W McGinnis, M Levine.   

Abstract

The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.

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Year:  1985        PMID： 3898362     DOI： 10.1126/science.3898362

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  69 in total

1.  Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex.

Authors:  Robert A Drewell; Esther Bae; John Burr; Edward B Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-11       Impact factor: 11.205

2.  A novel boundary element may facilitate independent gene regulation in the Antennapedia complex of Drosophila.

Authors:  Vladimir E Belozerov; Parimal Majumder; Ping Shen; Haini N Cai
Journal:  EMBO J       Date:  2003-06-16       Impact factor: 11.598

Review 3.  Synthesizing embryology and human genetics: paradigms regained.

Authors:  S F Gilbert
Journal:  Am J Hum Genet       Date:  1992-07       Impact factor: 11.025

Review 4.  Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.

Authors:  Daniel L Garaulet; Eric C Lai
Journal:  Mech Dev       Date:  2015-08-23       Impact factor: 1.882

5.  Transcriptional selectivity in early mouse embryos: a qualitative study.

Authors:  C Bonnerot; M Vernet; G Grimber; P Briand; J F Nicolas
Journal:  Nucleic Acids Res       Date:  1991-12       Impact factor: 16.971

6.  Duplicated Abd-B class genes in medaka hoxAa and hoxAb clusters exhibit differential expression patterns in pectoral fin buds.

Authors:  Naofumi Takamatsu; Gene Kurosawa; Masayoshi Takahashi; Ryouichi Inokuma; Minoru Tanaka; Akira Kanamori; Hiroshi Hori
Journal:  Dev Genes Evol       Date:  2007-02-27       Impact factor: 0.900

7.  Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.

Authors:  R S Jones; W M Gelbart
Journal:  Genetics       Date:  1990-09       Impact factor: 4.562

8.  The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

Authors:  A M Mazo; D H Huang; B A Mozer; I B Dawid
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

9.  Modulo, a new maternally expressed Drosophila gene encodes a DNA-binding protein with distinct acidic and basic regions.

Authors:  E Krejci; V Garzino; C Mary; N Bennani; J Pradel
Journal:  Nucleic Acids Res       Date:  1989-10-25       Impact factor: 16.971

10.  Comparative studies of Drosophila Antennapedia genes.

Authors:  J E Hooper; M Pérez-Alonso; J R Bermingham; M Prout; B A Rocklein; M Wagenbach; J E Edstrom; R de Frutos; M P Scott
Journal:  Genetics       Date:  1992-10       Impact factor: 4.562
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