Literature DB >> 389822

Efficacy of bacampicillin and ampicillin in experimental pyelonephritis in the rat.

W Ritzerfeld.   

Abstract

Bacampicillin and ampicillin were tested and compared with each other in a model of acute, obstructive pyelonephritis in the rat. The compounds were administered orally at five dose levels ranging from 50 mg/kg to 150 mg/kg. Bacampicillin was found to have a greater therapeutic activity than ampicillin, particulary at the higher doses, indicating that its improved absorption properties make it a therapeutically more effective compound than ampicillin.

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Year:  1979        PMID： 389822     DOI： 10.1007/bf01659767

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  3 in total

1.  [Pivampicillin and ampicillin in experimental E. coli pyelonephritis].

Authors:  S Hubmann; W Ritzerfeld
Journal:  Arzneimittelforschung       Date:  1975-02

2.  [Models of urinary infection].

Authors:  V Prát; M Hatala; L Konícková; W Ritzerfeld
Journal:  Zentralbl Bakteriol Orig A       Date:  1974

3.  Bacampicillin: a new orally well-absorbed derivative of ampicillin.

Authors:  N O Bodin; B Ekström; U Forsgren; L P Jalar; L Magni; C H Ramsay; B Sjöberg
Journal:  Antimicrob Agents Chemother       Date:  1975-11       Impact factor: 5.191
  3 in total
  1 in total

Review 1.  Studies on aminopenicillin developments. Proceedings of a symposium. Concluding remarks.

Authors:  T Bergan
Journal:  Infection       Date:  1979       Impact factor: 3.553
  1 in total

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