Literature DB >> 3897816

Protective immunity to systemic nocardiosis in mice immunized with cell extract antigens of Nocardia asteroides.

R Gupta, V Pancholi, V K Vinayak, G K Khuller.   

Abstract

Mice immunized with crude cell extract antigens of Nocardia asteroides as well as its purified fraction F1 elicited significant levels of both humoral and cellular immune responses. These animals when challenged with 50% lethal dose of N. asteroides, two weeks after the complete immunization exhibited significant protection as seen by decreased mortality and viable counts compared to nonimmunized. The immunized animals were capable of clearing the infection much faster as compared to control. Cell extract antigens which were mainly protein in nature are thought to have a prime role in prevention and restriction of nocardial infection.

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Year:  1985        PMID： 3897816     DOI： 10.1007/bf02298126

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  14 in total

1.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

2.  Resistance to infection with Nocardia asteroides.

Authors:  J A Krick; J S Remington
Journal:  J Infect Dis       Date:  1975-06       Impact factor: 5.226

3.  Infectious agents in immunodeficient murine models: pathogenicity of Nocardia asteroides in congenitally athymic (nude) and hereditarily asplenic (Dh/+) mice.

Authors:  B L Beaman; M E Gershwin; S Maslan
Journal:  Infect Immun       Date:  1978-05       Impact factor: 3.441

4.  Enhanced resistance to Nocardia brasiliensis infection in mice depleted of antigen-specific B cells.

Authors:  G Rico; R Ochoa; A Oliva; A Gonzalez-Mendoza; S M Walker; L Ortiz-Ortiz
Journal:  J Immunol       Date:  1982-10       Impact factor: 5.422

5.  Cell-mediated immunity to Nocardia asteroides induced by its ribonucleic acid protein fraction.

Authors:  T Sundararaj; S C Agarwal
Journal:  Infect Immun       Date:  1977-10       Impact factor: 3.441

6.  Interaction of Nocardia asteroides at different phases of growth with in vitro-maintained macrophages obtained from the lungs of normal and immunized rabbits.

Authors:  B L Beaman
Journal:  Infect Immun       Date:  1979-10       Impact factor: 3.441

7.  Adoptive transfer of immunity to Nocardia asteroides in nude mice.

Authors:  R L Deem; B L Beaman; M E Gershwin
Journal:  Infect Immun       Date:  1982-12       Impact factor: 3.441

8.  Effects of activated macrophages on Nacardia asteroides.

Authors:  G A Filice; B L Beaman; J S Remington
Journal:  Infect Immun       Date:  1980-02       Impact factor: 3.441

Review 9.  Human nocardiosis. A clinical review with selected case reports.

Authors:  W A Curry
Journal:  Arch Intern Med       Date:  1980-06

10.  Effects of human neutrophils and monocytes on Nocardia asteroides: failure of killing despite occurrence of the oxidative metabolic burst.

Authors:  G A Filice; B L Beaman; J A Krick; J S Remington
Journal:  J Infect Dis       Date:  1980-09       Impact factor: 5.226
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  1 in total

1.  Nocardia farcinica activates human dendritic cells and induces secretion of interleukin-23 (IL-23) rather than IL-12p70.

Authors:  Martin Eisenblätter; Ariane Buchal; Hermine Gayum; Edith Jasny; Pablo Renner Viveros; Timo Ulrichs; Thomas Schneider; Ralf R Schumann; Janine Zweigner; Ralf Ignatius
Journal:  Infect Immun       Date:  2012-09-17       Impact factor: 3.441
  1 in total

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