| Literature DB >> 3895338 |
G J van der Brugge-Gamelkoorn, B E Plesch, T Sminia, H L Langevoort.
Abstract
Histological changes in bronchus-associated lymphoid tissue (BALT) following single intratracheal administration of five different antigens were studied in the rat. After administration of T-dependent antigens (i.e., horseradish peroxidase, bovine serum albumin, and Bacillus Calmette Guérin) only minor changes in BALT in the rat occurred. Intratracheal administration of a T-independent antigen (lipopolysaccharide) and a partly T-independent antigen (paratyphoid vaccine) resulted after 1 week in an increase in cytoplasmic IgM-containing (cIgM) blast cells and plasma cells; these appeared to enter via the high endothelial venules (HEV). After 6 weeks, germinal centers were seen.Entities:
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Year: 1985 PMID: 3895338 DOI: 10.1159/000194795
Source DB: PubMed Journal: Respiration ISSN: 0025-7931 Impact factor: 3.580