Literature DB >> 3893506

Detection of placental-type alkaline phosphatase in ovarian cancer.

I W McDicken, P J McLaughlin, P M Tromans, D M Luesley, P M Johnson.   

Abstract

A monoclonal antibody, H317, has been used for the sensitive and specific detection of placental-type alkaline phosphatase (PLAP) in sera, solubilized tissue extracts and fixed tumour tissue sections from patients representing a variety of ovarian tumours. PLAP was detected in over 30% of these sera and in most solubilized tumour tissue extracts. There was no association between circulating PLAP levels and either tissue extract levels or immunohistological staining of ovarian tumour tissue sections with H317. Nevertheless, immunohistology demonstrated the heterogeneity of cellular localization of PLAP within different tumours, and can often be of value in localizing tumour tissue.

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Year:  1985        PMID： 3893506      PMCID： PMC1977171          DOI： 10.1038/bjc.1985.149

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  21 in total

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Authors:  W H Fishman; R M Singer
Journal:  Ann N Y Acad Sci       Date:  1975-08-22       Impact factor: 5.691

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Authors:  W H Fishman; N R Inglis; J Vaitukaitis; L L Stolbach
Journal:  Natl Cancer Inst Monogr       Date:  1975-10

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Journal:  Int Adv Surg Oncol       Date:  1979

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Authors:  J A Kellen; R S Bush; A Malkin
Journal:  Cancer Res       Date:  1976-01       Impact factor: 12.701

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Authors:  P J McLaughlin; M H Cheng; M B Slade; P M Johnson
Journal:  Int J Cancer       Date:  1982-07-15       Impact factor: 7.396

6.  Immunochemical studies of human placental-type variants of alkaline phosphatase. Structural differences between the "Nagao isoenzyme" and the placental "D-variant".

Authors:  S C Wei; G J Doellgast
Journal:  Eur J Biochem       Date:  1981-08

7.  The value of a sensitive assay of carcino-placental alkaline phosphatase (CPAP) in the follow-up of gynecological cancers.

Authors:  W G Haije; J H Meerwaldt; A Talerman; T j Kuipers; L Baggerman; A H Teeuw; W B van der Pompe; J van Driel
Journal:  Int J Cancer       Date:  1979-09-15       Impact factor: 7.396

8.  A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus.

Authors:  D J Goldstein; C Rogers; H Harris
Journal:  Clin Chim Acta       Date:  1982-10-13       Impact factor: 3.786

9.  Placental-like alkaline phosphatase in malignant and benign ovarian tumors.

Authors:  F J Benham; M S Povey; H Harris
Journal:  Clin Chim Acta       Date:  1978-06       Impact factor: 3.786

Review 10.  Biochemical markers in ovarian cancer: possibilities and limitations.

Authors:  W G Haije
Journal:  Ann Clin Biochem       Date:  1982-07       Impact factor: 2.057
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  8 in total

1.  Tumor markers in the human ovary and its neoplasms. A comparative immunohistochemical study.

Authors:  E J Nouwen; P G Hendrix; S Dauwe; M W Eerdekens; M E De Broe
Journal:  Am J Pathol       Date:  1987-02       Impact factor: 4.307

2.  Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract.

Authors:  T E Ind; R K Iles; P G Carter; D G Lowe; J H Shepherd; C N Hudson; T Chard
Journal:  J Clin Pathol       Date:  1994-11       Impact factor: 3.411

3.  Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.

Authors:  J L Millán; T Manes
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

4.  Placental alkaline phosphatase in developing normal and abnormal gonads and in germ-cell tumours.

Authors:  J Hustin; Y Gillerot; J Collette; P Franchimont
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1990

5.  Investigation of expression of 5T4 antigen in cervical cancer.

Authors:  H Jones; G Roberts; N Hole; I W McDicken; P Stern
Journal:  Br J Cancer       Date:  1990-01       Impact factor: 7.640

6.  A 72 kD trophoblast glycoprotein defined by a monoclonal antibody.

Authors:  N Hole; P L Stern
Journal:  Br J Cancer       Date:  1988-03       Impact factor: 7.640

7.  Placental-type alkaline phosphatase in cervical neoplasia.

Authors:  P J McLaughlin; P H Warne; G E Hutchinson; P M Johnson; D F Tucker
Journal:  Br J Cancer       Date:  1987-02       Impact factor: 7.640

8.  Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.

Authors:  Viktor Reiswich; Natalia Gorbokon; Andreas M Luebke; Eike Burandt; Anne Menz; Martina Kluth; Claudia Hube-Magg; Corinna Wittmer; Sören Weidemann; Christoph Fraune; Katharina Möller; Patrick Lebok; Guido Sauter; Ronald Simon; Ria Uhlig; Waldemar Wilczak; Frank Jacobsen; Sarah Minner; Rainer Krech; Christian Bernreuther; Andreas Marx; Stefan Steurer; Till Clauditz; Till Krech
Journal:  J Pathol Clin Res       Date:  2021-08-07
  8 in total

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