Literature DB >> 3892570

Temperature dependent modification of radiosensitivity following hypoxic cytocidal action of chlorpromazine.

M A Shenoy, B B Singh.   

Abstract

The hypoxic cytotoxic effect of chlorpromazine towards E. coli B/r was observed to be dependent on temperature of incubation and irradiation. Increasing the temperature of incubation from ambient to 37 degrees C followed by irradiation revealed that the organisms showed radiosensitivity of a magnitude which was two to three times the oxygen effect. The possible mechanisms of this effect are discussed.

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Year:  1985        PMID： 3892570     DOI： 10.1007/bf01229816

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN： 0301-634X            Impact factor:   1.925


  8 in total

1.  Effects of chlorpromazine on metabolism in central nervous system.

Authors:  R G GRENELL; J MENDELSON; W D McELROY
Journal:  AMA Arch Neurol Psychiatry       Date:  1955-03

2.  Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.

Authors:  B A Moore; B Palcic; L D Skarsgard
Journal:  Radiat Res       Date:  1976-09       Impact factor: 2.841

3.  Biochemical aspects of radiation sensitization of E. coli B/r by chlorpromazine.

Authors:  M A Shenoy; K Gopalakrishna
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1978-06

4.  Hypoxic cytotoxicity of chlorpromazine and the modification of radiation response in E. coli B/r.

Authors:  M A Shenoy; B B Singh
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1978-12

5.  Inhibition of cultured human tumor cell oxygen utilization by chlorpromazine.

Authors:  M A Shenoy; J E Biaglow; M E Varnes; F W Hetzel
Journal:  Adv Exp Med Biol       Date:  1983       Impact factor: 2.622

6.  The effect of radiation on tumour growth delay, cell survival and cure of the animal using a single tumour system.

Authors:  N J McNally; P W Sheldon
Journal:  Br J Radiol       Date:  1977-05       Impact factor: 3.039

7.  Modification of radiation effects in single-cell systems by membrane-binding agents.

Authors:  M A Shenoy; K C George; B B Singh; A R Gopal-Ayengar
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1975-12

8.  Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

Authors:  I J Stratford; G E Adams
Journal:  Br J Cancer       Date:  1977-03       Impact factor: 7.640
  8 in total

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