Literature DB >> 3892363

Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury.

C Y Hsu, P V Halushka, E L Hogan, N L Banik, W A Lee, P L Perot.   

Abstract

We measured levels of thromboxane B2 and 6-keto-PGF1 alpha in rabbit spinal cord and cat CSF after impact injury to spinal cord. Rabbit tissue thromboxane B2 levels increased more than 6-keto-PGF1 alpha. In cat, CSF thromboxane B2 was higher the first hour postinjury; CSF 6-keto-PGF1 alpha also increased, but less so. These results imply activation of arachidonic acid metabolism. The relatively greater increase of thromboxane B2 suggests that thromboxane-prostacyclin imbalance may contribute to post-traumatic ischemia.

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Year:  1985        PMID： 3892363     DOI： 10.1212/wnl.35.7.1003

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  9 in total

1.  The effects of chronic alpha-tocopherol administration on lipid peroxidation in an experimental model of acute spinal cord injury.

Authors:  M Bozbuğa; N Izgi; A Canbolat
Journal:  Neurosurg Rev       Date:  1998       Impact factor: 3.042

2.  Effect of partial ischemia on phospholipids and postischemic lipid peroxidation in rabbit spinal cord.

Authors:  G Halát; M Chavko; N Lukácová; D Kluchová; J Marsala
Journal:  Neurochem Res       Date:  1989-11       Impact factor: 3.996

3.  The effect of duration of compression on lipid peroxidation after experimental spinal cord injury.

Authors:  M Y Kaynar; M Hanci; A Kafadar; K Gümüştaş; A Belce; N Ciplak
Journal:  Neurosurg Rev       Date:  1998       Impact factor: 3.042

Review 4.  Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System.

Authors:  Tatsurou Yagami; Hiromi Koma; Yasuhiro Yamamoto
Journal:  Mol Neurobiol       Date:  2015-09-02       Impact factor: 5.590

5.  Administration of low dose estrogen attenuates persistent inflammation, promotes angiogenesis, and improves locomotor function following chronic spinal cord injury in rats.

Authors:  Supriti Samantaray; Arabinda Das; Denise C Matzelle; Shan P Yu; Ling Wei; Abhay Varma; Swapan K Ray; Naren L Banik
Journal:  J Neurochem       Date:  2016-04-12       Impact factor: 5.372

6.  Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis. Experimental study in the rat.

Authors:  H S Sharma; Y Olsson; J Cervós-Navarro
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

7.  Effect of intra-arachnoid space perfusion on thromboxane A and prostacycline in experimental spinal cord injury.

Authors:  Y Tu; J Du; Z Xia; L Wang
Journal:  J Tongji Med Univ       Date:  1997

8.  Correlation of alterations on Na(+)-K+/Mg+2 ATPase activity, lipid peroxidation and ultrastructural findings following experimental spinal cord injury with and without intravenous methylprednisolone treatment.

Authors:  F Ildan; A Oner; S Polat; T Isbir; A I Göcer; M Kaya; A Karadayi
Journal:  Neurosurg Rev       Date:  1995       Impact factor: 3.042

Review 9.  Therapeutic Hypothermia in Spinal Cord Injury: The Status of Its Use and Open Questions.

Authors:  Jiaqiong Wang; Damien D Pearse
Journal:  Int J Mol Sci       Date:  2015-07-24       Impact factor: 5.923
  9 in total

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