Review of the health effects of methylmercury.

The study critically reviews recent data relating to the health effects of methylmercury in man and the attendant dose-response relationships. New data obtained from animal studies, including pre-and postnatal exposure, are also examined. The consumption of fish and fish produce represents the major source of methylmercury exposure in the general population. Reported mercury concentrations in fish throughout the world are examined, particularly in the Mediterranean Sea. Here there is limited knowledge of methylmercury intake in critically exposed populations such as fishermen, employees of the fish industries and their families. The measurement of mercury in hair is now regarded as the most useful indicator of exposure but more experimental data are still required to increase the value of this index. The threshold levels of methylmercury in blood, hair and for dietary intake, as estimated by the World Health Organization, have been largely endorsed. However, new information from Japan and Canada suggests the existence of a latency period for some effects, so that the frequency or probability of their occurrence is inversely related to the duration of exposure. Incorporation of such findings would therefore lead to the designation of lower threshold values than are presently recognized. Pregnant women and the fetus have been identified as groups that are at special risk. The fetal blood mercury level is up to twice that of the mother and the sensitivity of both mother and fetus may be higher than in non-pregnant adults. This should be taken into account when assigning protective threshold concentrations.