Literature DB >> 3891581

Bovine superoxide dismutase in Fanconi anaemia. Therapeutic trial in two patients.

V Izakovic, E Strbáková, E Kaiserová, P Krizan.   

Abstract

Bovine superoxide dismutase (SOD) (Peroxinorm, Grünenthal Stolberg) was injected intramuscularly or subcutaneously in a daily dose of 4 mg over a period of six weeks into two patients with Fanconi anaemia. The effects (measured by the decrease of chromosome aberrations in blood lymphocytes and the increase in blood cells in venous blood) were evident but temporary. The hypothetical mode of action of SOD and the failure of a prolonged therapeutic effect are discussed.

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Year:  1985        PMID： 3891581     DOI： 10.1007/bf00273079

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  8 in total

1.  Effect of superoxide dismutase and catalase on spontaneously occurring chromosome breaks in patients with Fanconi's anemia.

Authors:  I Nordenson
Journal:  Hereditas       Date:  1977       Impact factor: 3.271

2.  The effect of superoxide dismutase, catalase and L-cysteine on spontaneous and on mitomycin C induced chromosomal breakage in Fanconi's anemia and normal fibroblasts as measured by the micronucleus method.

Authors:  A S Raj; J A Heddle
Journal:  Mutat Res       Date:  1980-05       Impact factor: 2.433

3.  Effect of superoxide dismutase on the chromosomal instability of New Zealand black mice.

Authors:  I Emerit; A Levy; A M Michelson
Journal:  Cytogenet Cell Genet       Date:  1981

4.  Effect of oxygen tension on chromosomal aberrations in Fanconi anaemia.

Authors:  H Joenje; A B Oostra
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

Review 5.  Genetically determined chromosome instability syndromes.

Authors:  T M Schroeder
Journal:  Cytogenet Cell Genet       Date:  1982

6.  Suppression of cytotoxic effect of mitomycin-C by superoxide dismutase in Fanconi's anemia and dyskeratosis congenita fibroblasts.

Authors:  H Nagasawa; J B Little
Journal:  Carcinogenesis       Date:  1983       Impact factor: 4.944

7.  Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia.

Authors:  H Joenje; F Arwert; A W Eriksson; H de Koning; A B Oostra
Journal:  Nature       Date:  1981-03-12       Impact factor: 49.962

8.  Cytogenetic toxicity of D2O in human lymphocyte cultures. Increased sensitivity in Fanconi's anemia.

Authors:  H Joenje; A B Oostra; A H Wanamarta
Journal:  Experientia       Date:  1983-07-15
  8 in total
  2 in total

1.  Superoxide dismutase activity in the Spanish population.

Authors:  M R De la Torre; A Casado; M E López-Fernández
Journal:  Experientia       Date:  1990-08-15

2.  Partial correction of chromosome instability in Fanconi anemia by desferrioxamine.

Authors:  B Porfirio; G Ambroso; G Giannella; G Isacchi; B Dallapiccola
Journal:  Hum Genet       Date:  1989-08       Impact factor: 4.132
  2 in total

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