Literature DB >> 3890912

The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.

J Hirtz.   

Abstract

The various mechanisms which have been advanced to explain drug absorption are critically reviewed and the limitations of current theories are discussed. Various techniques for investigating drug absorption and transit through the gut are presented, and the results obtained with metoprolol are briefly considered to illustrate the potential of some of these methods.

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Year:  1985        PMID： 3890912      PMCID： PMC1463764          DOI： 10.1111/j.1365-2125.1985.tb02746.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  25 in total

1.  Per cent absorbed time plots derived from blood level and/or urinary excretion data.

Authors:  J G WAGNER; E NELSON
Journal:  J Pharm Sci       Date:  1963-06       Impact factor: 3.534

2.  The influence of experimental procedures and dose on the intestinal absorption of an onium compound, benzomethamine.

Authors:  R R LEVINE; E W PELIKAN
Journal:  J Pharmacol Exp Ther       Date:  1961-03       Impact factor: 4.030

3.  Studies of intestinal digestion and absorption in the human.

Authors:  B BORGSTROM; A DAHLQVIST; G LUNDH; J SJOVALL
Journal:  J Clin Invest       Date:  1957-10       Impact factor: 14.808

4.  The gastric secretion of drugs: a pH partition hypothesis.

Authors:  P A SHORE; B B BRODIE; C A HOGBEN
Journal:  J Pharmacol Exp Ther       Date:  1957-03       Impact factor: 4.030

5.  An incremental method for the study of the absorption of drugs whose kinetics are described by a two-compartment model: estimation of the microscopic rate constants.

Authors:  A Gerardin; D Wantiez; A Jaouen
Journal:  J Pharmacokinet Biopharm       Date:  1983-08

Review 6.  Drugs, diseases and altered gastric emptying.

Authors:  W S Nimmo
Journal:  Clin Pharmacokinet       Date:  1976       Impact factor: 6.447

7.  Kinetics of acetaminophen absorption and gastric emptying in man.

Authors:  J A Clements; R C Heading; W S Nimmo; L F Prescott
Journal:  Clin Pharmacol Ther       Date:  1978-10       Impact factor: 6.875

8.  Influence of food on the absorption of acetylsalicylic acid from enteric-coated dosage forms.

Authors:  C Bogentoft; I Carlsson; G Ekenved; A Magnusson
Journal:  Eur J Clin Pharmacol       Date:  1978-12-18       Impact factor: 2.953

9.  An evaluation of indium DTPA chelate in the measurement of gastric emptying by scintiscanning.

Authors:  R C Heading; P Tothill; A J Laidlaw; D J Shearman
Journal:  Gut       Date:  1971-08       Impact factor: 23.059

10.  Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

Authors:  G Jobin; A Cortot; J Godbillon; M Duval; J P Schoeller; J Hirtz; J J Bernier
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335
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  17 in total

1.  A mechanism-based approach for absorption modeling: the Gastro-Intestinal Transit Time (GITT) model.

Authors:  Emilie Hénin; Martin Bergstrand; Joseph F Standing; Mats O Karlsson
Journal:  AAPS J       Date:  2012-06       Impact factor: 4.009

Review 2.  Floating drug delivery systems: a review.

Authors:  Shweta Arora; Javed Ali; Alka Ahuja; Roop K Khar; Sanjula Baboota
Journal:  AAPS PharmSciTech       Date:  2005-10-19       Impact factor: 3.246

Review 3.  Oral bioavailability: issues and solutions via nanoformulations.

Authors:  Kamla Pathak; Smita Raghuvanshi
Journal:  Clin Pharmacokinet       Date:  2015-04       Impact factor: 6.447

4.  Dose-dependent absorption and elimination of cefadroxil in man.

Authors:  T M Garrigues; U Martin; J E Peris-Ribera; L F Prescott
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

5.  The effects of pharmaceutical excipients on small intestinal transit.

Authors:  D A Adkin; S S Davis; R A Sparrow; P D Huckle; A J Phillips; I R Wilding
Journal:  Br J Clin Pharmacol       Date:  1995-04       Impact factor: 4.335

6.  Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.

Authors:  S S Davis; N Washington; G D Parr; A H Short; V A John; P Lloyd; S M Walker
Journal:  Br J Clin Pharmacol       Date:  1988-10       Impact factor: 4.335

7.  G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res 12, 413-420, 1995--backstory of BCS.

Authors:  Vinod P Shah; Gordon L Amidon
Journal:  AAPS J       Date:  2014-06-25       Impact factor: 4.009

Review 8.  A Review of Food-Drug Interactions on Oral Drug Absorption.

Authors:  Jianyuan Deng; Xiao Zhu; Zongmeng Chen; Chun Ho Fan; Him Shek Kwan; Chi Ho Wong; Ka Yi Shek; Zhong Zuo; Tai Ning Lam
Journal:  Drugs       Date:  2017-11       Impact factor: 9.546

9.  A convective-diffusion model for dissolution of two non-interacting drug mixtures from co-compressed slabs under laminar hydrodynamic conditions.

Authors:  S Neervannan; L S Dias; M Z Southard; V J Stella
Journal:  Pharm Res       Date:  1994-09       Impact factor: 4.200

10.  Floating tablet of trimetazidine dihydrochloride: an approach for extended release with zero-order kinetics.

Authors:  Ahmed Abdelbary; Omaima N El-Gazayerly; Nashwa A El-Gendy; Adel A Ali
Journal:  AAPS PharmSciTech       Date:  2010-06-26       Impact factor: 3.246
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