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Literature DB >> 3890733

Aztreonam therapy in experimental meningitis due to Haemophilus influenzae type b and Escherichia coli K1.

Abstract

The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1985 PMID： 3890733 PMCID： PMC180117 DOI： 10.1128/AAC.27.4.655

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. Serial dilution antibiotic sensitivity testing with the microtitrator system.

Authors: J H Marymont; R M Wentz
Journal: Am J Clin Pathol Date: 1966-05 Impact factor: 2.493

2. Comparative in vitro study of SQ26,776.

Authors: V Fainstein; S Weaver; G P Bodey
Journal: Antimicrob Agents Chemother Date: 1982-02 Impact factor: 5.191

3. Pharmacokinetics and therapeutic efficacy of imipenem, ceftazidime, and ceftriaxone in experimental meningitis due to an ampicillin- and chloramphenicol-resistant strain of Haemophilus influenzae type b.

Authors: Y Sakata; G H McCracken; M L Thomas; K D Olsen
Journal: Antimicrob Agents Chemother Date: 1984-01 Impact factor: 5.191

4. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.

Authors: R B Sykes; D P Bonner; K Bush; N H Georgopapadakou
Journal: Antimicrob Agents Chemother Date: 1982-01 Impact factor: 5.191

5. Pharmacokinetics and bacteriological efficacy of cefoperazone, ceftriaxone, and moxalactam in experimental Streptococcus pneumoniae and Haemophilus influenzae meningitis.

Authors: G H McCracken; J D Nelson; L Grimm
Journal: Antimicrob Agents Chemother Date: 1982-02 Impact factor: 5.191

6. Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.

Authors: R G Dacey; M A Sande
Journal: Antimicrob Agents Chemother Date: 1974-10 Impact factor: 5.191

7. Evaluation of aztreonam in experimental bacterial meningitis and cerebritis.

Authors: W M Scheld; J P Brodeur; J C Gratz; P Foresman; G Rodeheaver
Journal: Antimicrob Agents Chemother Date: 1983-11 Impact factor: 5.191

8. Pharmacokinetics and bacteriological efficacy of moxalactam (LY127935), netilmicin, and ampicillin in experimental gram-negative enteric bacillary meningitis.

Authors: U B Schaad; G H McCracken; C A Loock; M L Thomas
Journal: Antimicrob Agents Chemother Date: 1980-03 Impact factor: 5.191

9. Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli meningitis.

Authors: Y Sakata; A Boccazzi; G H McCracken
Journal: Antimicrob Agents Chemother Date: 1983-02 Impact factor: 5.191

10. Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis.

Authors: U B Schaad; G H McCracken; C A Loock; M L Thomas
Journal: J Infect Dis Date: 1981-02 Impact factor: 5.226

4 in total

1. Penetration of aztreonam into cerebrospinal fluid and brain of noninfected rabbits and rabbits with experimental meningitis caused by Pseudomonas aeruginosa.

Authors: L J Strausbaugh; C R Bodem; P R Laun
Journal: Antimicrob Agents Chemother Date: 1986-11 Impact factor: 5.191