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Literature DB >> 389062

In vitro evaluation of radiation-induced augmentation of the immune response.

Abstract

Small doses (5--25 rads) of radiation augment the in vitro response of murine spleen cells to sheep red blood cells (SRBCs). Such augmentation appears to result from radiation-induced disruption of a homeostatic component of the response that exerts maximum effect soon after the introduction of antigen. Evidence is presented to support the concept that augmentation is due to injury of an exquisitely radiosensitive subpopulation of T cells with suppressor activity.

Entities: Species

Mesh：

Year: 1979 PMID： 389062 PMCID： PMC2042414

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

23 in total

Review 1. Ionizing radiation and the immune response.

Authors: R E Anderson; N L Warner
Journal: Adv Immunol Date: 1976 Impact factor: 3.543

2. Relation of primary antigen injection to time of irradiation on antibody production in mice.

Authors: N GENGOZIAN; T MAKINODAN
Journal: J Immunol Date: 1958-03 Impact factor: 5.422

3. Radiosensitivity of T and B lymphocytes. IV. Effect of whole body irradiation upon various lymphoid tissues and numbers of recirculating lymphocytes.

Authors: R E Anderson; G B Olson; J R Autry; J L Howarth; G M Troup; P H Bartels
Journal: J Immunol Date: 1977-04 Impact factor: 5.422

4. Radiosensitivity of defined populations of lymphocytes. VI. Functional, structural, and biochemical consequences of in vitro irradiation.

Authors: R E Anderson; J C Standefer; J V Scaletti
Journal: Cell Immunol Date: 1977-09 Impact factor: 4.868

5. Murine T-cell preparations: radiosensitivity of helper activity.

Authors: D A Lawrence; A Eastman; W O Weigle
Journal: Cell Immunol Date: 1978-03-01 Impact factor: 4.868

6. Activation of human B lymphocytes. VIII. Differential radiosensitivity of subpopulations of lymphoid cells involved in the polyclonally-induced PFC responses of peripheral blood B lymphocytes.

Authors: A S Fauci; K R Pratt; G Whalen
Journal: Immunology Date: 1978-11 Impact factor: 7.397

7. Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.

Authors: H Cantor; J Hugenberger; L McVay-Boudreau; D D Eardley; J Kemp; F W Shen; R K Gershon
Journal: J Exp Med Date: 1978-10-01 Impact factor: 14.307

In vitro evaluation of radiation-induced augmentation of the immune response.

Review 1. Ionizing radiation and the immune response.

2. Relation of primary antigen injection to time of irradiation on antibody production in mice.

3. Radiosensitivity of T and B lymphocytes. IV. Effect of whole body irradiation upon various lymphoid tissues and numbers of recirculating lymphocytes.

4. Radiosensitivity of defined populations of lymphocytes. VI. Functional, structural, and biochemical consequences of in vitro irradiation.

5. Murine T-cell preparations: radiosensitivity of helper activity.

6. Activation of human B lymphocytes. VIII. Differential radiosensitivity of subpopulations of lymphoid cells involved in the polyclonally-induced PFC responses of peripheral blood B lymphocytes.

7. Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.

8. Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population.

9. Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.

10. Enhancement of antibody formation by whole body x-radiation.

1. Partial reversal of radiation-induced immunosuppression by T-lymphocyte lysate.

2. The aging process.

3. Radiation-induced augmentation of the response of A/J mice to SaI tumor cells.

4. Shifting the paradigm in radiation safety.

Review 5. Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications.