Literature DB >> 3889159

LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes.

S J Mentzer, S H Gromkowski, A M Krensky, S J Burakoff, E Martz.   

Abstract

We report here that MAb to human LFA-1 inhibit spontaneous homotypic adhesions of human B lymphocytes. This is, to our knowledge, the first report of a MAb that inhibits human homotypic intercellular adhesions for any cell type. LFA-1 has previously been recognized as a molecule capable of regulating specific immunologic adhesions between T lymphocytes and antigen-bearing target cells. The present findings show that the role of LFA-1 is not limited to adhesions initiated by specific immunologic recognition. The results indicate that the LFA-1 molecule is capable of regulating lymphocyte adhesions, possibly because it is a direct participant in adhesion formation.

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Year:  1985        PMID： 3889159

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  14 in total

1.  Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact.

Authors:  D Schwartz; R C Wong; T Chatila; A Arnaout; R Miller; R Geha
Journal:  J Clin Immunol       Date:  1989-03       Impact factor: 8.317

2.  CD43 interferes with T-lymphocyte adhesion.

Authors:  B Ardman; M A Sikorski; D E Staunton
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

3.  Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri.

Authors:  P Geck; S A Whitaker; M M Medveczky; P G Medveczky
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

4.  Mechanisms of lymphocyte adhesion to human vascular endothelial cells in culture. T lymphocyte adhesion to endothelial cells through endothelial HLA-DR antigens induced by gamma interferon.

Authors:  J Masuyama; N Minato; S Kano
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

5.  Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18.

Authors:  N Dana; D M Fathallah; M A Arnaout
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

6.  Mechanisms of lymphocyte adhesion to endothelial cells: studies using a LFA-1-deficient cell line.

Authors:  D O Haskard; S Strobel; M Thornhill; C Pitzalis; R J Levinsky
Journal:  Immunology       Date:  1989-01       Impact factor: 7.397

7.  Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones.

Authors:  S J Mentzer; B E Bierer; D C Anderson; T A Springer; S J Burakoff
Journal:  J Clin Invest       Date:  1986-11       Impact factor: 14.808

8.  Interleukin-4-mediated aggregation of anti-IgM-stimulated human B cells: inhibition of aggregation but enhancement of proliferation by antibodies to LFA-1.

Authors:  P Björck; S Paulie; B Axelsson
Journal:  Immunology       Date:  1992-01       Impact factor: 7.397

9.  Expression of the collagen-like putative oncoprotein of Herpesvirus saimiri in transformed T cells.

Authors:  M M Medveczky; P Geck; R Vassallo; P G Medveczky
Journal:  Virus Genes       Date:  1993-12       Impact factor: 2.332

10.  Activation of T lymphocytes by immobilized monoclonal antibodies to CD3. Regulatory influences of monoclonal antibodies to additional T cell surface determinants.

Authors:  T D Geppert; P E Lipsky
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808
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