Ambulatory electrocardiographic monitoring: can we predict sudden death?

Cardiac arrhythmias can be accurately detected and quantified using ambulatory electrocardiographic monitoring. From a review of major studies, it appears that the presence of advanced ventricular arrhythmias identifies a subset of patients with coronary heart disease who are at a relatively higher risk for sudden death than are those patients without such arrhythmias. Left ventricular dysfunction is an independent and additive risk factor for subsequent development of sudden cardiac death. The presence of high grade ventricular arrhythmias appears to increase the risk for sudden death in patients with hypertrophic and dilated cardiomyopathy. Ambulatory monitoring can be used to identify a subset of patients with coronary disease or cardiomyopathy who are at increased risk for sudden cardiac death. Because of the relatively low overall incidence of sudden cardiac death in such patients, and the low sensitivity and specificity for accurately classifying patients, the practical applicability of this technique to large population subgroups is limited.