Literature DB >> 3888662

Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde.

M H Perrard.   

Abstract

Exposure of several trp-auxotrophic Escherichia coli strains, carrying base-pair substitutions, to chloroethylene oxide or chloroacetaldehyde (two metabolites of vinyl chloride) increased the mutation frequency to tryptophan prototrophy. Strong cytotoxic and mutagenic effects were observed with 2.5 mM chloroethylene oxide, while a higher concentration of chloroacetaldehyde (100 mM) exhibited a mutagenic effect which was 400 times lower.

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Year:  1985        PMID： 3888662     DOI： 10.1007/bf02007715

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanol.

Authors:  C Malaveille; H Bartsch; A Barbin; A M Camus; R Montesano; A Croisy; P Jacquignon
Journal:  Biochem Biophys Res Commun       Date:  1975-03-17       Impact factor: 3.575

2.  Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride.

Authors:  A Barbin; H Brésil; A Croisy; P Jacquignon; C Malaveille; R Montesano; H Bartsch
Journal:  Biochem Biophys Res Commun       Date:  1975-11-17       Impact factor: 3.575

3.  Transduction of linked genetic characters of the host by bacteriophage P1.

Authors:  E S LENNOX
Journal:  Virology       Date:  1955-07       Impact factor: 3.616

4.  Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation.

Authors:  G Bonse; T Urban; D Reichert; D Henschler
Journal:  Biochem Pharmacol       Date:  1975-10-01       Impact factor: 5.858

5.  Amino acid replacements and the genetic code.

Authors:  C Yanofsky; J Ito; V Horn
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1966

6.  Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains.

Authors:  H Bartsch; C Malaveille; R Montesano
Journal:  Int J Cancer       Date:  1975-03-15       Impact factor: 7.396

Review 7.  Mutagenic and carcinogenic effects of vinyl chloride.

Authors:  H Bartsch; R Montesano
Journal:  Mutat Res       Date:  1975       Impact factor: 2.433

8.  Normal and mutant glycine transfer RNAs.

Authors:  C Squires; J Carbon
Journal:  Nat New Biol       Date:  1971-10-27

9.  The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride.

Authors:  U Rannug; R Göthe; C A Wachtmeister
Journal:  Chem Biol Interact       Date:  1976-03       Impact factor: 5.192

10.  Mutational specificity of the base analogue, 2-aminopurine, in Escherichia coli.

Authors:  D H Persing; L McGinty; C W Adams; R G Fowler
Journal:  Mutat Res       Date:  1981-08       Impact factor: 2.433
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  1 in total

Review 1.  N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations.

Authors:  N P Vermeulen; J de Jong; E J van Bergen; R T van Welie
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153
  1 in total

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