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Literature DB >> 3888661

Malignant hyperthermia: molecular defects in membrane permeability.

Abstract

Malignant hyperthermia (MH), a genetically inherited disorder of skeletal muscle, is due to molecular defect in membrane permeability. The alteration in membrane permeability is suggested to be due to enhanced phospholipase A2 activity which is responsible for the increased level in sarcoplasmic Ca2+. The excess Ca2+ is responsible for muscle hyper-rigidity and enhanced rate of glycolysis, resulting in a rapid rate of lactic acid production and a low pH in MH muscle.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 1985 PMID： 3888661 DOI： 10.1007/bf02007707

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

126 in total

1. Calmodulin stimulates human platelet phospholipase A2.

Authors: P Y Wong; W Y Cheung
Journal: Biochem Biophys Res Commun Date: 1979-09-27 Impact factor: 3.575

2. The regulation of skeletal muscle phosphorylase kinase by Ca2+.

Authors: C O Brostrom; F L Hunkeler; E G Krebs
Journal: J Biol Chem Date: 1971-04-10 Impact factor: 5.157

3. Hereditary aspects of malignant hyperthermia.

Authors: B A Britt; W G Locher; W Kalow
Journal: Can Anaesth Soc J Date: 1969-03

4. Skeletal muscle mitochondrial phospholipase A2 and the interaction of mitochondria and sarcoplasmic reticulum in porcine malignant hyperthermia.

Authors: K S Cheah; A M Cheah
Journal: Biochim Biophys Acta Date: 1981-11-12

5. A simple and sensitive colorimetric method for the determination of long-chain free fatty acids in subcellular organelles.

Authors: M Nixon; S H Chan
Journal: Anal Biochem Date: 1979-09-01 Impact factor: 3.365

6. Halothane-induced porcine malignant hyperthermia: metabolic and hemodynamic changes.

Authors: G A Gronert; R A Theye
Journal: Anesthesiology Date: 1976-01 Impact factor: 7.892

7. Skeletal muscle sarcoplasmic reticulum in porcine malignant hyperthermia.

Authors: G A Gronert; J J Heffron; S R Taylor
Journal: Eur J Pharmacol Date: 1979-09-15 Impact factor: 4.432

8. Malignant hyperpyrexia. Further muscle studies in asymptomatic carriers identified by creatinine phosphokinase screening.

Authors: H Isaacs; M B Barlow
Journal: J Neurol Neurosurg Psychiatry Date: 1973-04 Impact factor: 10.154

Malignant hyperthermia: molecular defects in membrane permeability.

1. Calmodulin stimulates human platelet phospholipase A2.

2. The regulation of skeletal muscle phosphorylase kinase by Ca2+.

3. Hereditary aspects of malignant hyperthermia.

4. Skeletal muscle mitochondrial phospholipase A2 and the interaction of mitochondria and sarcoplasmic reticulum in porcine malignant hyperthermia.

5. A simple and sensitive colorimetric method for the determination of long-chain free fatty acids in subcellular organelles.

6. Halothane-induced porcine malignant hyperthermia: metabolic and hemodynamic changes.

7. Skeletal muscle sarcoplasmic reticulum in porcine malignant hyperthermia.

8. Malignant hyperpyrexia. Further muscle studies in asymptomatic carriers identified by creatinine phosphokinase screening.

9. The effect of dantrolene on skeletal-muscle sarcoplasmic-reticulum function in malignant hyperpyrexia in pigs.

10. Temperature perturbation studies of sarcoplasmic reticulum from malignant hyperthermia pig muscle.

Review 1. Mechanisms of exercise-induced muscle fibre injury.

2. Membrane abnormality in malignant hyperthermia.