Literature DB >> 3888226

Damage of Trypanosoma cruzi deoxyribonucleic acid by nitroheterocyclic drugs.

S G Goijman, A C Frasch, A O Stoppani.   

Abstract

Kinetoplast DNA (kDNA) from Trypanosoma cruzi epimastigotes pretreated with the trypanocidal drugs nifurtimox (10 or 100 microM) or benznidazole (38 or 380 microM) showed an increased number of strand-breaks, as revealed by (a) trapping of alkali-denatured kDNA by nitrocellulose filters and (b) electrophoresis in an alkaline 2% agarose gel. Similar damage was observed in nuclear DNA (nDNA), as detected by centrifugation in an alkaline-sucrose gradient. DNA damage was reversible since reincubation in fresh medium for 24 hr restored filtration and electrophoretic and sedimentation patterns to normal.

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Year:  1985        PMID： 3888226     DOI： 10.1016/0006-2952(85)90684-7

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  9 in total

1.  Putrescine analogue cytotoxicity against Trypanosoma cruzi.

Authors:  D Menezes; C Valentim; M F Oliveira; M A Vannier-Santos
Journal:  Parasitol Res       Date:  2005-11-11       Impact factor: 2.289

2.  Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi.

Authors:  E G Díaz de Toranzo; J A Castro; B M Franke de Cazzulo; J J Cazzulo
Journal:  Experientia       Date:  1988-10-15

3.  Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata.

Authors:  M N de Tarlovsky; S G Goijman; M P Molina Portela; A O Stoppani
Journal:  Experientia       Date:  1990-05-15

4.  Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.

Authors:  Belinda S Hall; Christopher Bot; Shane R Wilkinson
Journal:  J Biol Chem       Date:  2011-02-23       Impact factor: 5.157

5.  Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.

Authors:  Andrea Trochine; Darren J Creek; Paula Faral-Tello; Michael P Barrett; Carlos Robello
Journal:  PLoS Negl Trop Dis       Date:  2014-05-22

6.  Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma cruzi.

Authors:  Diego A Rojas; Fabiola Urbina; Sandra Moreira-Ramos; Christian Castillo; Ulrike Kemmerling; Michel Lapier; Juan Diego Maya; Aldo Solari; Edio Maldonado
Journal:  PLoS Negl Trop Dis       Date:  2018-02-12

7.  Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites.

Authors:  Melissa Louise Sykes; David Hugh Hilko; Livia Isabella Kung; Sally-Ann Poulsen; Vicky Marie Avery
Journal:  PLoS Negl Trop Dis       Date:  2020-03-12

8.  Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.

Authors:  Boris Rodenko; Martin J Wanner; Abdulsalam A M Alkhaldi; Godwin U Ebiloma; Rebecca L Barnes; Marcel Kaiser; Reto Brun; Richard McCulloch; Gerrit-Jan Koomen; Harry P de Koning
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191

9.  Prostaglandin F2α synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole.

Authors:  Paola García-Huertas; Ana María Mejía-Jaramillo; Carlos Renato Machado; Anna Cláudia Guimarães; Omar Triana-Chávez
Journal:  R Soc Open Sci       Date:  2017-09-20       Impact factor: 2.963
  9 in total

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