Literature DB >> 3888219

Ethanol inhibits hormone stimulated hepatocyte DNA synthesis.

E A Carter, J R Wands.   

Abstract

Insulin, glucagon, and epidermal growth factor (EGF) addition stimulated DNA synthesis in primary hepatocyte cell cultures prepared from adult rat liver. The addition of ethanol (20-200mM) to the culture medium resulted in a substantial reduction in DNA synthesis as measured by 3H-thymidine incorporation and autoradiography. This effect was specific for differentiated hepatocytes compared to fibroblasts and two other human hepatoma cell lines. These studies demonstrate in a cell culture system that one of the major properties of ethanol is the inhibition of hepatocyte DNA synthesis.

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Year:  1985        PMID： 3888219     DOI： 10.1016/0006-291x(85)90113-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and rapamycin-sensitive mechanism in fibroblasts and JB6 cells.

Authors:  Z Kiss; W H Anderson; J J Mukherjee
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

Review 2.  The pathogenesis of alcoholic liver disease.

Authors:  R Goldin
Journal:  Int J Exp Pathol       Date:  1994-04       Impact factor: 1.925

3.  Insulin-induced differentiation and modulation of neuronal thread protein expression in primitive neuroectodermal tumor cells is linked to phosphorylation of insulin receptor substrate-1.

Authors:  Y Y Xu; K Bhavani; J R Wands; S M de la Monte
Journal:  J Mol Neurosci       Date:  1995       Impact factor: 3.444

4.  Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver.

Authors:  J Chen; E J Ishac; P Dent; G Kunos; B Gao
Journal:  Biochem J       Date:  1998-09-15       Impact factor: 3.857

5.  Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression.

Authors:  Y Y Xu; K Bhavani; J R Wands; S M de la Monte
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

6.  Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance.

Authors:  Sarah M Denucci; Ming Tong; Lisa Longato; Margot Lawton; Mashiko Setshedi; Rolf I Carlson; Jack R Wands; Suzanne M de la Monte
Journal:  Gastroenterol Res Pract       Date:  2010-08-16       Impact factor: 2.260

7.  Effect of ethanol on polyamine synthesis during liver regeneration in rats.

Authors:  A M Diehl; M Wells; N D Brown; S S Thorgeirsson; C J Steer
Journal:  J Clin Invest       Date:  1990-02       Impact factor: 14.808

8.  Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration.

Authors:  B H Zhang; B P Hornsfield; G C Farrell
Journal:  J Clin Invest       Date:  1996-09-01       Impact factor: 14.808

9.  Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth.

Authors:  Wey-Ran Lin; Ming-Wei Lai; Chau-Ting Yeh
Journal:  Oncol Rep       Date:  2012-12-24       Impact factor: 3.906

Review 10.  The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids.

Authors:  Suzanne M de la Monte; Lisa Longato; Ming Tong; Sarah DeNucci; Jack R Wands
Journal:  Int J Environ Res Public Health       Date:  2009-07-23       Impact factor: 3.390
  10 in total

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