Literature DB >> 3887570

Function and autoregulation of yeast copperthionein.

D H Hamer, D J Thiele, J E Lemontt.   

Abstract

The CUP1 gene of yeast encodes a small, metallothionein-like protein that binds to and is inducible by copper. A gene replacement experiment shows that this protein protects cells against copper poisoning but is dispensable for normal cellular growth and development throughout the yeast life cycle. The transcription of CUP1 is negatively autoregulated. This feedback mechanism, which is mediated through upstream control sequences, may play an important role in heavy metal homeostasis.

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Year:  1985        PMID： 3887570     DOI： 10.1126/science.3887570

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  63 in total

1.  Remodeling of yeast CUP1 chromatin involves activator-dependent repositioning of nucleosomes over the entire gene and flanking sequences.

Authors:  C H Shen; B P Leblanc; J A Alfieri; D J Clark
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

2.  Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae.

Authors:  Kenneth James Howe; Caroline M Kane; Manuel Ares
Journal:  RNA       Date:  2003-08       Impact factor: 4.942

3.  Differential expression of a metallothionein gene during the presymbiotic versus the symbiotic phase of an arbuscular mycorrhizal fungus.

Authors:  Luisa Lanfranco; Angelo Bolchi; Emanuele Cesale Ros; Simone Ottonello; Paola Bonfante
Journal:  Plant Physiol       Date:  2002-09       Impact factor: 8.340

4.  Saccharomyces cerevisiae and Neurospora crassa contain heavy metal sequestering phytochelatin.

Authors:  R Kneer; T M Kutchan; A Hochberger; M H Zenk
Journal:  Arch Microbiol       Date:  1992       Impact factor: 2.552

5.  Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract.

Authors:  V C Culotta; T Hsu; S Hu; P Fürst; D Hamer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

6.  Different patterns of regulation for the copper and cadmium metallothioneins of the ectomycorrhizal fungus Hebeloma cylindrosporum.

Authors:  G Ramesh; G K Podila; G Gay; R Marmeisse; M S Reddy
Journal:  Appl Environ Microbiol       Date:  2009-02-20       Impact factor: 4.792

7.  Regulation of Saccharomyces cerevisiae catalase gene expression by copper.

Authors:  P Lapinskas; H Ruis; V Culotta
Journal:  Curr Genet       Date:  1993-11       Impact factor: 3.886

Review 8.  The many highways for intracellular trafficking of metals.

Authors:  Edward Luk; Laran T Jensen; Valeria C Culotta
Journal:  J Biol Inorg Chem       Date:  2003-09-27       Impact factor: 3.358

9.  Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways.

Authors:  K T Tamai; X Liu; P Silar; T Sosinowski; D J Thiele
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein.

Authors:  S A Knight; K T Tamai; D J Kosman; D J Thiele
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272
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